Stohl W, Cunningham-Rundles C, Thompson C, Mayer L
Clin Immunol Immunopathol. 1986 Nov;41(2):273-80. doi: 10.1016/0090-1229(86)90111-x.
Sera were collected from patients with common varied immunodeficiency (CVI) prior to and following intravenous gamma-globulin (IVGG) infusion. Cultures of pokeweed mitogen (PWM)-stimulated peripheral blood mononuclear cells from normal donors in medium containing post-IVGG infusion sera generated significantly fewer plaque-forming cells (PFC) than those cultures in medium containing the corresponding pre-IVGG infusion sera. However, preinfusion CVI sera were found to be similar to normal sera in their capacities to support PWM-induced PFC generation, despite the disparity in Ig levels between the two groups of sera. Furthermore, serum collected from a CVI patient 24 hr or more after IVGG infusion no longer possessed the same inhibitory capacity as serum collected 10 min after IVGG infusion despite elevated IgG levels compared to baseline. These studies suggest that IVGG infusion may induce an immunosuppressive effect which is transient in nature, raising the possibility of in vivo counterbalancing homeostatic mechanisms responding to this immune perturbation.
在静脉注射丙种球蛋白（IVGG）之前和之后，从普通变异型免疫缺陷（CVI）患者中采集血清。在含有IVGG输注后血清的培养基中，来自正常供体的美洲商陆有丝分裂原（PWM）刺激的外周血单个核细胞培养物产生的空斑形成细胞（PFC）明显少于含有相应IVGG输注前血清的培养基中的培养物。然而，尽管两组血清之间的Ig水平存在差异，但发现输注前的CVI血清在支持PWM诱导的PFC生成的能力方面与正常血清相似。此外，IVGG输注24小时或更长时间后从CVI患者收集的血清不再具有与IVGG输注10分钟后收集的血清相同的抑制能力，尽管与基线相比IgG水平升高。这些研究表明，IVGG输注可能会诱导一种本质上是短暂的免疫抑制作用，增加了体内平衡机制对这种免疫扰动做出反应的体内平衡机制的可能性。
