Abenoza P, Manivel J C, Swanson P E, Wick M R
Hum Pathol. 1986 Nov;17(11):1107-15. doi: 10.1016/s0046-8177(86)80415-4.
To analyze the purportedly epithelial features of synovial sarcoma, the antigenic profiles of 20 of these neoplasms (including 12 of the monophasic type) were studied by three different immunohistochemical techniques, and the results were correlated with ultrastructural observations in 10 cases. All of the biphasic tumors were immunoreactive for the epithelial markers epithelial membrane antigen (EMA) and cytokeratin (CK) and also had ultrastructural features of epithelial differentiation. In contrast, only one of five monophasic tumors had electron microscopic features suggestive of epithelial differentiation, but eight of the 12 were immunoreactive for CK or EMA by a procedure combining the peroxidase-antiperoxidase and avidin-biotin-peroxidase complex methods. It is concluded that synovial sarcoma, including the monophasic variant, is a mesenchymal tumor with epithelial features. Immunohistochemical studies are more sensitive than ultrastructural analysis for documenting epithelial differentiation.
为分析滑膜肉瘤所谓的上皮特征，采用三种不同的免疫组织化学技术研究了20例此类肿瘤（包括12例单相型）的抗原谱，并将结果与10例的超微结构观察结果进行了对比。所有双相性肿瘤对上皮标志物上皮膜抗原（EMA）和细胞角蛋白（CK）呈免疫反应，并且还具有上皮分化的超微结构特征。相比之下，5例单相性肿瘤中只有1例具有提示上皮分化的电镜特征，但通过过氧化物酶-抗过氧化物酶和抗生物素蛋白-生物素-过氧化物酶复合物方法相结合的程序，12例中有8例对CK或EMA呈免疫反应。得出的结论是，滑膜肉瘤，包括单相型变体，是一种具有上皮特征的间叶性肿瘤。免疫组织化学研究在记录上皮分化方面比超微结构分析更敏感。
