环孢素A对小鼠B细胞对TI抗原和B细胞有丝分裂原的反应具有不同的影响。
Cyclosporin A has differential effects on the responses of murine B cells to TI antigens and B-cell mitogens.
作者信息
Higham A D, Sells R A, Marshall-Clarke S
出版信息
Immunology. 1986 Oct;59(2):203-7.
The effect of cyclosporin A (CyA) on the response of murine splenocytes to B-cell mitogens, TI-1 and TI-2 antigens was investigated. The proliferative response to LPS was found to be four- to five-fold less sensitive to inhibition than that to dextran sulphate. Antibody responses to a TI-2 antigen in vivo were suppressed by CyA treatment, whereas responses to the TI-1 antigen DNP-LPS were markedly enhanced. Enhanced antibody responses to DNP-LPS were also demonstrable in vitro in the presence of CyA, and the enhancement was not removed by T-cell depletion. LPS-induced antibody production in vitro was enhanced at the same CyA concentrations that inhibited proliferation by 40-50%. The implications of these findings for the mechanism of action of CyA and for our understanding of B-cell differentiation are discussed.
研究了环孢素A（CyA）对小鼠脾细胞对B细胞丝裂原、TI-1和TI-2抗原反应的影响。发现对脂多糖（LPS）的增殖反应对抑制的敏感性比对硫酸葡聚糖低四至五倍。体内对TI-2抗原的抗体反应被CyA处理所抑制，而对TI-1抗原二硝基苯-脂多糖（DNP-LPS）的反应则明显增强。在体外，在有CyA存在的情况下，对DNP-LPS的抗体反应增强也得到证实，并且这种增强不会因T细胞耗竭而消除。在体外，LPS诱导的抗体产生在相同的CyA浓度下增强，而该浓度可抑制增殖40%-50%。讨论了这些发现对CyA作用机制以及我们对B细胞分化理解的意义。
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