Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
Immunology. 2014 Apr;141(4):483-9. doi: 10.1111/imm.12224.
Human natural killer (NK) cells have distinct functions as NK(tolerant) , NK(cytotoxic) and NK(regulatory) cells and can be divided into different subsets based on the relative expression of the surface markers CD27 and CD11b. CD27⁺ NK cells, which are abundant cytokine producers, are numerically in the minority in human peripheral blood but constitute the large population of NK cells in cord blood, spleen, tonsil and decidua tissues. Recent data suggest that these NK cells may have immunoregulatory properties under certain conditions. In this review, we will focus on these new NK cell subsets and discuss how regulatory NK cells may serve as rheostats or sentinels in controlling inflammation and maintaining immune homeostasis in various organs.
人类自然杀伤 (NK) 细胞具有不同的功能，如 NK（耐受）、NK（细胞毒性）和 NK（调节）细胞，并可以根据表面标记物 CD27 和 CD11b 的相对表达水平分为不同的亚群。CD27+ NK 细胞是丰富的细胞因子产生者，在人类外周血中数量较少，但在脐血、脾脏、扁桃体和蜕膜组织中构成 NK 细胞的主要群体。最近的数据表明，在某些条件下，这些 NK 细胞可能具有免疫调节特性。在这篇综述中，我们将重点介绍这些新的 NK 细胞亚群，并讨论调节性 NK 细胞如何在控制炎症和维持各种器官的免疫平衡中充当变阻器或哨兵。
