*Division of Cancer Policy and Management, National Cancer Control Research Institute, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Korea.
Jpn J Clin Oncol. 2014 Feb;44(2):141-52. doi: 10.1093/jjco/hyt184. Epub 2013 Dec 4.
We assessed health-related quality of life in cancer survivors treated in designated cancer centers when compared with the general population in Korea.
A multicenter survey was conducted from July through August 2008 using the quota-sampling approach. A general population sample was drawn from the Fourth Korean National Health and Nutrition Examination Survey, second year. We compared the multivariate-adjusted least square means of cancer patients with those of the general population to examine relationships between EuroQol five-dimensional questionnaire components and cancer sites, cancer stage and time since diagnosis. The independent variables of responses to the EuroQol five-dimensional questionnaire were evaluated using logistic regression analysis.
Cancer patients scored significantly poorer on measures of self-care (means: stomach 1.25; lung 1.40; liver 1.27; colon 1.26; breast 1.27; cervical 1.29 vs. general 1.18), engagement in usual activities (means: stomach 1.47; lung 1.63; liver 1.45; colon 1.44; breast 1.46; cervical 1.47 vs. general 1.33) and anxiety/depression (means: stomach 1.41; lung 1.50; liver 1.41; colon 1.42; breast 1.50; cervical 1.47 vs. general 1.28). Those in the local stage scored significantly better on mobility (mean = 1.35) than the general population (mean = 1.40). Cancer patients, especially those with lung cancer, in the advanced stage and more than 5 years since diagnosis had poorer health-related quality of life than the general population. Some factors such as medical insurance and healthcare services were related to health-related quality of life among cancer patients.
Health-related quality of life of cancer survivors with lung cancer at advanced stages, <1 year earlier and more than 5 years since diagnosis was poorer than that for the non-cancer control group, and these differences were statistically significant. Cancer survivors should be continuously observed and offered support.
与韩国一般人群相比，评估在指定癌症中心治疗的癌症幸存者的健康相关生活质量。
2008 年 7 月至 8 月，采用配额抽样法进行了一项多中心调查。从第四次韩国国家健康和营养检查调查的第二年中抽取一般人群样本。我们比较了癌症患者和一般人群的多维调整最小二乘平均值，以检查 EuroQol 五维问卷成分与癌症部位、癌症分期和诊断后时间之间的关系。使用逻辑回归分析评估对 EuroQol 五维问卷的反应的自变量。
癌症患者在自我护理（平均值：胃 1.25；肺 1.40；肝 1.27；结肠 1.26；乳房 1.27；宫颈 1.29 与一般 1.18）、从事日常活动（平均值：胃 1.47；肺 1.63；肝 1.45；结肠 1.44；乳房 1.46；宫颈 1.47 与一般 1.33）和焦虑/抑郁（平均值：胃 1.41；肺 1.50；肝 1.41；结肠 1.42；乳房 1.50；宫颈 1.47 与一般 1.28）方面的得分明显较差。局部阶段的患者在移动性方面的得分（平均值=1.35）明显优于一般人群（平均值=1.40）。处于晚期且诊断后 5 年以上的癌症患者的健康相关生活质量明显差于一般人群。一些因素，如医疗保险和医疗服务，与癌症患者的健康相关生活质量有关。
处于晚期、<1 年前和诊断后 5 年以上的肺癌癌症幸存者的健康相关生活质量差于非癌症对照组，且这些差异具有统计学意义。癌症幸存者应持续观察并提供支持。
