[福氏志贺菌O抗原多糖主链重复单元及其二聚体的合成]
[Synthesis of a repeating unit and the dimer of the repeating unit of the major chain of Shigella flexneri O-antigen polysaccharide].
作者信息
Tsvetkov Iu E, Baĭramova N E, Bakinovskiĭ L V, Kochetkov N K, Iankina N F
出版信息
Bioorg Khim. 1986 Sep;12(9):1213-24.
PMID:2430581
Abstract
Methyl glycoside of the tetrasaccharide GlcNAc(beta 1-2)Rha(alpha 1-2)Rha(alpha 1-3)Rha, which represents a repeating unit of the basic chain of Shigella flexneri O-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons. A dimer of the repeating unit, octasaccharide [GlcNAc(beta 1-2)Rha(alpha 1-2) Rha(alpha 1-3)Rha(alpha 1-3)]2-OMe was obtained by TrClO4-catalyzed condensation of two tetrasaccharide blocks.
摘要
四糖GlcNAc(β1-2)Rha(α1-2)Rha(α1-3)Rha的甲基糖苷代表弗氏志贺氏菌O抗原多糖基本链的重复单元，它是使用酰化单糖合成子合成的。通过高氯酸铊催化两个四糖片段的缩合反应，得到了重复单元的二聚体八糖[GlcNAc(β1-2)Rha(α1-2)Rha(α1-3)Rha(α1-3)]2-OMe。
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