宋内志贺氏菌O-特异性多糖寡糖片段的免疫化学分析
[Immunochemical analysis of oligosaccharide fragments of O-specific Shigella flexneri polysaccharides].
作者信息
Iankina N F, Gomtsian A R, Bakinovskiĭ L V
出版信息
Bioorg Khim. 1984 Oct;10(10):1421-2.
Comparison of inhibitory properties of several synthetic oligosaccharides related to Sh. flexneri O-specific polysaccharides, namely Glc alpha 1-3Rha alpha 1-OMe, Glc alpha 1-3Rha alpha 1-2Rha alpha 1-OMe, Rha alpha 1-2(Glc alpha 1-3)Rha alpha 1-OMe, GlcNAc beta 1-2(Glc alpha 1-3)Rha alpha 1-OMe, and GlcNAc beta 1-2(Glc alpha 1-3) Rha alpha 1-2Rha alpha 1-OMe, using passive haemagglutination reaction demonstrated the tetrasaccharide to possess the highest activity in V; 7,8-anti-7,8 immune system. Among the oligosaccharides under study, only Rha alpha 1-2(Glc alpha 1-3)Rha alpha 1-OMe exhibited moderate anti-V activity.
对几种与弗氏志贺菌O-特异性多糖相关的合成寡糖，即α-D-吡喃葡萄糖基-(1→3)-α-L-鼠李糖基-(1→O-甲基)、α-D-吡喃葡萄糖基-(1→3)-α-L-鼠李糖基-(1→2)-α-L-鼠李糖基-(1→O-甲基)、α-L-鼠李糖基-(1→2)-[α-D-吡喃葡萄糖基-(1→3)]-α-L-鼠李糖基-(1→O-甲基)、N-乙酰-β-D-吡喃葡萄糖胺基-(1→2)-[α-D-吡喃葡萄糖基-(1→3)]-α-L-鼠李糖基-(1→O-甲基)以及N-乙酰-β-D-吡喃葡萄糖胺基-(1→2)-[α-D-吡喃葡萄糖基-(1→3)]-α-L-鼠李糖基-(1→2)-α-L-鼠李糖基-(1→O-甲基)的抑制特性进行比较，采用被动血凝反应证明四糖在V;7,8-抗7,8免疫系统中具有最高活性。在所研究的寡糖中，只有α-L-鼠李糖基-(1→2)-[α-D-吡喃葡萄糖基-(1→3)]-α-L-鼠李糖基-(1→O-甲基)表现出中等的抗V活性。
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