miR-141 对人骨肉瘤的抑瘤作用。

Tumor-suppressing effects of miR-141 in human osteosarcoma.

机构信息

Department of Orthopedics of Jinling Hospital, Nanjing University, School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, China.

出版信息

Cell Biochem Biophys. 2014 Jun;69(2):319-25. doi: 10.1007/s12013-013-9801-7.

DOI:10.1007/s12013-013-9801-7

PMID:24307282

Abstract

Osteosarcoma is the most common primary malignancy to arise from bone. The pathogenesis of osteosarcoma is unclear, and new therapy molecular target is needed. The miRNAs researched suggested that miRNAs are involved in the pathogenesis of osteosarcoma. MiR-141, which belong to miR-200 family, take a part in tumorigenesis. However, the role of miR-141 in the pathogenesis of osteosarcoma remained unclear. In this study, we focused on the miR-141 in osteosarcoma and found that the expression of miR-141 is lower in osteosarcoma. Overexpression of miR-141 not only inhibits osteosarcoma cell proliferation but also induces cell apoptosis. It is estimated that miR-141 played its role via ZEB1 and ZEB2. In all, miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2. Our finding may elucidate the miRNAs mechanism in osteosarcoma and provide a new molecule target for osteosarcoma therapy.

摘要

骨肉瘤是最常见的原发于骨的恶性肿瘤。骨肉瘤的发病机制尚不清楚，需要新的治疗分子靶点。研究表明 miRNAs 参与了骨肉瘤的发病机制。miR-141 属于 miR-200 家族，参与肿瘤的发生。然而，miR-141 在骨肉瘤发病机制中的作用尚不清楚。在本研究中，我们专注于 miR-141 在骨肉瘤中的作用，发现 miR-141 在骨肉瘤中的表达较低。过表达 miR-141 不仅抑制骨肉瘤细胞增殖，还诱导细胞凋亡。据估计，miR-141 通过 ZEB1 和 ZEB2 发挥作用。总之，miR-141 通过 ZEB1 和 ZEB2 发挥骨肉瘤抑制作用。我们的发现可能阐明了 miRNAs 在骨肉瘤中的作用机制，并为骨肉瘤治疗提供了新的分子靶点。