Department of Orthopedics, Augusta University, Augusta, GA, United States.
Department of Orthopedics, Augusta University, Augusta, GA, United States; Department of Cell biology and Anatomy, Augusta University, Augusta, GA, United States; Institute of Regenerative and Reparative medicine, Augusta University, Augusta, GA, United States; Charlie Norwood VA Medical Center, Augusta, GA, United States.
Mech Ageing Dev. 2019 Mar;178:9-15. doi: 10.1016/j.mad.2018.12.001. Epub 2018 Dec 7.
MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3' UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Additionally, with aging, it is noted that there is dysregulation in the normal function of stem cell differentiation, bone formation/degradation, chondrocyte function, and muscle degeneration. Due to the change in expression of miRNA in degenerative musculoskeletal pathology, it is believed that these molecules may be at least partially responsible for cellular dysfunction. A number of miRNAs have already been identified to play a role in osteoarthritis, osteoporosis and sarcopenia. One miRNA that has become of interest recently is miRNA 141. The purpose of this article is to review the current literature available on miRNA 141 and how it could play a role in osteoporosis, osteoarthritis and musculoskeletal pathology overall.
MicroRNA 是一类小的非编码 RNA，通过靶向 mRNA 的 3'UTR 来调节基因的表达。研究表明，miRNA 在正常的肌肉骨骼功能中发挥着关键作用，如间充质干细胞的分化、存活和凋亡、成骨和软骨形成。正常 miRNA 表达的变化与许多病理疾病过程有关。此外，随着年龄的增长，人们注意到干细胞分化、骨形成/降解、软骨细胞功能和肌肉退化的正常功能出现失调。由于在退行性肌肉骨骼病理学中 miRNA 的表达发生变化，人们认为这些分子至少部分负责细胞功能障碍。已经确定了许多 miRNA 在骨关节炎、骨质疏松症和肌肉减少症中发挥作用。最近引起关注的一种 miRNA 是 miRNA 141。本文的目的是回顾 miRNA 141 的现有文献，以及它如何在骨质疏松症、骨关节炎和整体肌肉骨骼病理学中发挥作用。
