Jenny Alexis Lionel, Meyer Antonia, Handabaka Ivana, Calabrese Pasquale, Fuhr Peter, Gschwandtner Ute
Department of Neurology, Hospital of the University of Basel, Petersgraben 4, Basel 4031, Switzerland.
Division of Molecular and Cognitive Neuroscience, Neuropsychology and Behavioural Neurology Unit, University of Basel, Basel, Switzerland.
Parkinsons Dis. 2020 Apr 20;2020:7953032. doi: 10.1155/2020/7953032. eCollection 2020.
Parkinson's disease (PD) is associated with cognitive decline, progressing from subjective memory complaints (SMC) via mild cognitive impairment (MCI) to dementia. SMC are only measurable by an interview and thus rely on individuals reporting a subjectively perceived worsening of cognitive functioning. Cognitive decline is accompanied by a reduction in quality of life (QoL); however, the extent to which SMC manifest a reduction of QoL remains unclear.
To determine the association between SMC and deterioration of QoL in patients suffering from PD.
A total of 46 cognitively unimpaired PD patients (29 men and 17 women) completed PDQ-39, two assessments to measure SMC (Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and a Self-Assessment questionnaire), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Multiple regression modelling was conducted to investigate the confounding effect of depression and anxiety.
The PDQ-39 domain cognitions, but not the PDQ-39 sum score, correlated significantly with the SMC Self-Assessment questionnaire ( = 0.57; < 0.001). The conducted regression model indicates a significant confounding effect of depression and anxiety ( < 0.001, = 0.55).
In our study, SMC is significantly related to a reduction of cognitive QoL. In addition, we observed significant relation to anxiety and depression levels. In contrast to our main hypothesis, we found no association with overall QoL; this lack of association could be due to unstandardized questionnaires and emphasizes the need of validated tools for evaluating SMC.
帕金森病（PD）与认知功能衰退相关，从主观记忆障碍（SMC）开始，经轻度认知障碍（MCI）发展至痴呆。SMC只能通过访谈来衡量，因此依赖个体报告主观感觉到的认知功能恶化情况。认知功能衰退伴随着生活质量（QoL）下降；然而，SMC在多大程度上表现出生活质量下降仍不清楚。
确定PD患者中SMC与生活质量恶化之间的关联。
共有46名认知未受损的PD患者（29名男性和17名女性）完成了帕金森病问卷-39项（PDQ-39）、两项用于测量SMC的评估（老年人认知衰退知情者问卷（IQCODE）和一份自我评估问卷）、贝克抑郁量表（BDI）和贝克焦虑量表（BAI）。进行多元回归建模以研究抑郁和焦虑的混杂效应。
PDQ-39的认知领域，而非PDQ-39总分，与SMC自我评估问卷显著相关（r = 0.57；P < 0.001）。所进行的回归模型表明抑郁和焦虑有显著的混杂效应（P < 0.001，r = 0.55）。
在我们的研究中，SMC与认知生活质量下降显著相关。此外，我们观察到与焦虑和抑郁水平有显著关联。与我们的主要假设相反，我们发现与总体生活质量无关联；这种缺乏关联可能是由于问卷未标准化，并强调需要经过验证的工具来评估SMC。
