Truchado Daniel A, Moens Michaël A J, Callejas Sergio, Pérez-Tris Javier, Benítez Laura
Departamento de Biodiversidad, Ecología y Evolución, Facultad de Biología, Universidad Complutense de Madrid, Calle José Antonio Novais 12, 28040, Madrid, Spain.
Departamento de Fisiología, Genética y Microbiología, Facultad de Biología, Calle José Antonio Novais 12, 28040, Madrid, Spain.
Vet Res Commun. 2018 Jun;42(2):111-120. doi: 10.1007/s11259-018-9713-5. Epub 2018 Feb 14.
Papillomaviruses are non-enveloped, DNA viruses that infect skin and mucosa of a wide variety of vertebrates, causing neoplasias or simply persisting asymptomatically. Avian papillomaviruses, with six fully sequenced genomes, are the second most studied group after mammalian papillomaviruses. In this study, we describe the first oral avian papillomavirus, detected in the tongue of a dead Yorkshire canary (Serinus canaria) and in oral swabs of the same bird and other two live canaries from an aviary in Madrid, Spain. Its genome is 8,071 bp and presents the canonical papillomavirus architecture with six early (E6, E7, E1, E9, E2, E4) and two late open reading frames (L1 and L2) and a long control region between L1 and E6. This new avian papillomavirus L1 gene shares a 64% pairwise identity with FcPV1 L1, so it has been classified as a new species (ScPV1) within the Ethapapillomavirus genus. Although the canary died after showing breathing problems, there is no evidence that the papillomavirus caused those symptoms so it could be part of the oral microbiota of the birds. Hence, future investigations are needed to evaluate the clinical relevance of the virus.
乳头瘤病毒是无包膜的DNA病毒，可感染多种脊椎动物的皮肤和黏膜，导致肿瘤形成或仅无症状持续存在。禽乳头瘤病毒有六个已完全测序的基因组，是继哺乳动物乳头瘤病毒之后研究第二多的类群。在本研究中，我们描述了首例禽口腔乳头瘤病毒，它是在一只死亡的约克郡金丝雀（Serinus canaria）的舌头以及同一只鸟和来自西班牙马德里一个鸟舍的另外两只活金丝雀的口腔拭子中检测到的。其基因组为8071 bp，呈现出典型的乳头瘤病毒结构，有六个早期开放阅读框（E6、E7、E1、E9、E2、E4）和两个晚期开放阅读框（L1和L2），以及L1和E6之间的一个长控制区。这种新的禽乳头瘤病毒L1基因与FcPV1 L1的成对同一性为64%，因此它已被归类为Ethapapillomavirus属内的一个新物种（ScPV1）。尽管这只金丝雀在出现呼吸问题后死亡，但没有证据表明乳头瘤病毒导致了这些症状，所以它可能是鸟类口腔微生物群的一部分。因此，需要进一步的研究来评估该病毒的临床相关性。
