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黑色素瘤发病率上升——是皮肤细胞损伤过多还是修复太少?

Increasing melanoma-too many skin cell damages or too few repairs?

机构信息

Hallberg Independent Research, Brattforsgatan 3, 123 50 Farsta, Sweden.

出版信息

Cancers (Basel). 2013 Feb 18;5(1):184-204. doi: 10.3390/cancers5010184.

Abstract

Skin melanoma rates have been increasing for a long time in many Western countries. The object of this study was to apply modern problem-solving theory normally used to clear industrial problems to search for roots and causes of this medical question. Increasing cancer rates can be due to too many cell damage incidents or to too few repairs. So far, it has been assumed that the melanoma epidemic mainly is caused by increasing sun tanning habits. In order to explore this problem in more detail, we used cancer statistics from several countries over time and space. Detailed analysis of data obtained and a model study to evaluate the effects from increased damages or decreased repairs clearly indicate that the main reason behind the melanoma problem is a disturbed immune system. The possibility to introduce efficient corrective actions is apparent.

摘要

皮肤黑色素瘤的发病率在许多西方国家已经持续很长时间呈上升趋势。本研究的目的是将通常用于解决工业问题的现代问题解决理论应用于寻找这个医学问题的根源和原因。癌症发病率的增加可能是由于细胞损伤事件过多或修复过少。到目前为止,人们一直认为黑色素瘤的流行主要是由于越来越多的日光浴习惯所致。为了更详细地探讨这个问题,我们使用了来自不同国家和不同时间的癌症统计数据。对获得的数据进行详细分析以及进行模型研究以评估增加的损害或减少的修复的影响,清楚地表明黑色素瘤问题的主要原因是免疫系统紊乱。显然,有引入有效纠正措施的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bd2/3730314/ae16f20594c7/cancers-05-00184-g001.jpg

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