Durand M, Ramanathan R
J Pediatr. 1986 Dec;109(6):1052-6. doi: 10.1016/s0022-3476(86)80298-0.
We studied 54 neonates with acute cardiorespiratory illness and 21 infants with bronchopulmonary dysplasia, to evaluate the accuracy of a nonheated pulse oximeter in predicting arterial oxygen saturation (SaO2). We also studied the accuracy of transcutaneous oxygen tension (tcPO2) in estimating arterial oxygen tension (PaO2) in infants with bronchopulmonary dysplasia. We compared pulse oximeter SaO2 with simultaneously measured SaO2 (range 78% to 100%) using a co-oximeter. Over a wide range of values for heart rate, blood pressure, hematocrit, PO2, PCO2, and pH, linear regression analysis revealed a close correlation between in vivo pulse oximeter readings and in vitro SaO2 measurements in patients with acute (r = 0.86, Y = 29.64 + 0.68X) and chronic (r = 0.91, Y = 6.29 + 0.96X) disease. Regression analysis of tcPO2 versus PaO2 showed an r value of 0.76 in infants with bronchopulmonary dysplasia. In these patients the mean difference between pulse oximeter SaO2 and in vitro SaO2 was 2.9% +/- 1.8% (SD), whereas the mean difference between tcPO2 and PaO2 was -14.5 +/- 11.1 mm Hg. Fetal hemoglobin ranged from 4.3% to 95%. We conclude that pulse oximetry is an appropriate alternative to tcPO2 for continuous oxygen monitoring in newborn infants with acute cardiorespiratory illnesses and chronic lung disease.
我们研究了54例患有急性心肺疾病的新生儿和21例患有支气管肺发育不良的婴儿，以评估非加热式脉搏血氧仪预测动脉血氧饱和度（SaO2）的准确性。我们还研究了经皮氧分压（tcPO2）在评估支气管肺发育不良婴儿动脉氧分压（PaO2）方面的准确性。我们使用血气分析仪将脉搏血氧仪测得的SaO2与同时测量的SaO2（范围为78%至100%）进行比较。在心率、血压、血细胞比容、PO2、PCO2和pH值的广泛范围内，线性回归分析显示，急性疾病（r = 0.86，Y = 29.64 + 0.68X）和慢性疾病（r = 0.91，Y = 6.29 + 0.96X）患者体内脉搏血氧仪读数与体外SaO2测量值之间存在密切相关性。对tcPO2与PaO2进行回归分析，结果显示支气管肺发育不良婴儿的r值为0.76。在这些患者中，脉搏血氧仪测得的SaO2与体外SaO2之间的平均差异为2.9%±1.8%（标准差），而tcPO2与PaO2之间的平均差异为-14.5±11.1 mmHg。胎儿血红蛋白范围为4.3%至95%。我们得出结论，对于患有急性心肺疾病和慢性肺病的新生儿，脉搏血氧测定法是连续氧监测中tcPO2的合适替代方法。
