Song Shimao, Zhu Shengming, Zhang Zhiguo, Mo Zhengying, Ke Qing, Luo Zhiguo
Department of Oncology, Taihe Hospital Affiliated of Hubei University of Medicine, Shiyan 442000, China.
Afr J Tradit Complement Altern Med. 2013 Oct 3;10(6):435-8. doi: 10.4314/ajtcam.v10i6.5. eCollection 2013.
The objective of this paper was to investigate the antitumour mechanism of action of matrine by studying its inhibitory effect on gastric cancer SGC-7901 cells. SGC-7901 cells were chosen, and cell-killing capacity of matrine on gastric cancer SGC-7901 cells was determined using MTT assay and single PI staining assay. The results showed that matrine had an inhibitory effect on gastric cancer SGC-7901 cells, which was somewhat dose-dependent. The study concluded that matrine has a significant in-vitro inhibitory effect on SGC-7901 tumour cells, influences cell cycle of SGC-7901 cells, and induces their apoptosis.
本文的目的是通过研究苦参碱对胃癌SGC - 7901细胞的抑制作用来探讨其抗肿瘤作用机制。选用SGC - 7901细胞，采用MTT法和单碘化丙啶（PI）染色法测定苦参碱对胃癌SGC - 7901细胞的杀伤能力。结果表明，苦参碱对胃癌SGC - 7901细胞有抑制作用，且呈一定的剂量依赖性。该研究得出结论，苦参碱对SGC - 7901肿瘤细胞具有显著的体外抑制作用，影响SGC - 7901细胞的细胞周期，并诱导其凋亡。
