苦参碱对胃癌SGC - 7901细胞抑制作用的研究
A study on the inhibitory effect of matrine on gastric cancer SGC-7901 cells.
作者信息
Song Shimao, Zhu Shengming, Zhang Zhiguo, Mo Zhengying, Ke Qing, Luo Zhiguo
机构信息
Department of Oncology, Taihe Hospital Affiliated of Hubei University of Medicine, Shiyan 442000, China.
出版信息
Afr J Tradit Complement Altern Med. 2013 Oct 3;10(6):435-8. doi: 10.4314/ajtcam.v10i6.5. eCollection 2013.
The objective of this paper was to investigate the antitumour mechanism of action of matrine by studying its inhibitory effect on gastric cancer SGC-7901 cells. SGC-7901 cells were chosen, and cell-killing capacity of matrine on gastric cancer SGC-7901 cells was determined using MTT assay and single PI staining assay. The results showed that matrine had an inhibitory effect on gastric cancer SGC-7901 cells, which was somewhat dose-dependent. The study concluded that matrine has a significant in-vitro inhibitory effect on SGC-7901 tumour cells, influences cell cycle of SGC-7901 cells, and induces their apoptosis.
本文的目的是通过研究苦参碱对胃癌SGC - 7901细胞的抑制作用来探讨其抗肿瘤作用机制。选用SGC - 7901细胞，采用MTT法和单碘化丙啶（PI）染色法测定苦参碱对胃癌SGC - 7901细胞的杀伤能力。结果表明，苦参碱对胃癌SGC - 7901细胞有抑制作用，且呈一定的剂量依赖性。该研究得出结论，苦参碱对SGC - 7901肿瘤细胞具有显著的体外抑制作用，影响SGC - 7901细胞的细胞周期，并诱导其凋亡。
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