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From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change.从视盘临床检查到视乳头临床评估：范式转变。
Am J Ophthalmol. 2013 Aug;156(2):218-227.e2. doi: 10.1016/j.ajo.2013.04.016. Epub 2013 Jun 12.
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Identifying content for the glaucoma-specific item bank to measure quality-of-life parameters.为青光眼专用题库确定用于测量生活质量参数的内容。
J Glaucoma. 2015 Jan;24(1):12-9. doi: 10.1097/IJG.0b013e318287ac11.
3
Impact of glaucoma on visual functioning in Indians.青光眼对印度人视觉功能的影响。
Invest Ophthalmol Vis Sci. 2012 Sep 12;53(10):6081-92. doi: 10.1167/iovs.12-9885.
4
Visual field staging systems in glaucoma and the activities of daily living.青光眼的视野分期系统与日常生活活动。
Am J Ophthalmol. 2012 Sep;154(3):445-451.e3. doi: 10.1016/j.ajo.2012.03.030. Epub 2012 May 24.
5
Reengineering the glaucoma quality of life-15 questionnaire with rasch analysis.运用 Rasch 分析对青光眼生活质量-15 问卷进行重构。
Invest Ophthalmol Vis Sci. 2011 Sep 1;52(9):6971-7. doi: 10.1167/iovs.11-7423.
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[Measurement of glaucoma-specific functionality with the GQL-15 and correlation with parameters of visual function].[使用GQL-15测量青光眼特异性功能及其与视觉功能参数的相关性]
Ophthalmologe. 2011 Oct;108(10):939-46. doi: 10.1007/s00347-011-2402-1.
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Questionnaires for measuring cataract surgery outcomes.白内障手术结果测量问卷。
J Cataract Refract Surg. 2011 May;37(5):945-59. doi: 10.1016/j.jcrs.2011.03.010.
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Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point.青光眼的视网膜神经纤维层与视觉功能丧失：临界点。
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9
Comparison of the diagnostic accuracies of the Spectralis, Cirrus, and RTVue optical coherence tomography devices in glaucoma.比较 Spectralis、Cirrus 和 RTVue 光学相干断层扫描仪在青光眼诊断中的准确性。
Ophthalmology. 2011 Jul;118(7):1334-9. doi: 10.1016/j.ophtha.2010.11.029. Epub 2011 Mar 5.
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The impact of vision impairment on vision-specific quality of life in Germany.视力损伤对德国视功能特定生活质量的影响。
Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3613-9. doi: 10.1167/iovs.10-7127.

青光眼患者的结构和功能参数对患者自述视觉功能的影响。

The impact of structural and functional parameters in glaucoma patients on patient-reported visual functioning.

作者信息

Hirneiß Christoph, Reznicek Lukas, Vogel Michaela, Pesudovs Konrad

机构信息

Ludwig-Maximilians University, Department of Ophthalmology, Klinikum der Universität Muenchen, Campus Innenstadt, Munich, Germany.

出版信息

PLoS One. 2013 Dec 3;8(12):e80757. doi: 10.1371/journal.pone.0080757. eCollection 2013.

DOI:10.1371/journal.pone.0080757
PMID:24312500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3849027/
Abstract

BACKGROUND

To evaluate the impact of structural changes of the retinal nerve fiber layer (RNFL), and visual field loss, on functional impairment assessed by patient-reported visual functioning in glaucoma.

METHODS

Patients with glaucomatous optic nerve damage were enrolled in this cross-sectional study. Peripapillary RNFL thickness was obtained with spectral-domain optical coherence tomography (SD-OCT). Function was assessed by patient-reported visual functioning using the Rasch-calibrated Glaucoma Activity Limitation 9 (GAL-9) questionnaire and standard automated perimetry. The impact of peripapillary RNFL loss on functional impairment was analyzed with correlation and linear regression analyses.

RESULTS

A total of 176 eyes from 88 glaucoma patients were included. The SD-OCT assessed temporal-superior and temporal-inferior RNFL sector of the worse eye revealed significant correlation with the GAL-9 scores (r=-0.298, p=0.011 and r=-0.251, p=0.033, respectively). In mutivariate regression analysis, the best predictors for patient-reported visual functioning were visual acuity of the better eye and mean defect of the worse eye (R(2)=0.334), while structural parameters could not enhance the prediction of GAL-9 scores.

CONCLUSIONS

Self-reported visual functioning of patients with glaucoma is better predicted by visual performance data than structural parameters. However, some structural changes of the worse eye are significantly correlated with patient-reported visual functioning.

摘要

背景

评估视网膜神经纤维层（RNFL）结构变化和视野缺损对青光眼患者报告的视觉功能评估的功能损害的影响。

方法

青光眼性视神经损伤患者纳入本横断面研究。采用光谱域光学相干断层扫描（SD-OCT）测量视乳头周围RNFL厚度。使用经过Rasch校准的青光眼活动受限9（GAL-9）问卷和标准自动视野检查法，通过患者报告的视觉功能评估功能。采用相关性分析和线性回归分析，分析视乳头周围RNFL丢失对功能损害的影响。

结果

共纳入88例青光眼患者的176只眼。SD-OCT评估较差眼的颞上和颞下RNFL扇区与GAL-9评分显著相关（分别为r=-0.298，p=0.011和r=-0.251，p=0.033）。在多变量回归分析中，患者报告的视觉功能的最佳预测指标是较好眼的视力和较差眼的平均缺损（R(2)=0.334），而结构参数不能增强对GAL-9评分的预测。

结论

与结构参数相比，视觉性能数据能更好地预测青光眼患者自我报告的视觉功能。然而，较差眼的一些结构变化与患者报告的视觉功能显著相关。