• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Dichloromethane and Methanol Extracts of Scrophularia oxysepala Induces Apoptosis in MCF-7 Human Breast Cancer Cells.尖萼玄参的二氯甲烷和甲醇提取物诱导MCF-7人乳腺癌细胞凋亡。
Adv Pharm Bull. 2012;2(2):223-31. doi: 10.5681/apb.2012.034. Epub 2012 Aug 15.
2
Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.玄参提取物的二氯甲烷馏分诱导MCF-7人乳腺癌细胞凋亡。
Bosn J Basic Med Sci. 2015 Jan 29;15(1):26-32. doi: 10.17305/bjbms.2015.1.226.
3
Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems.体外和体内系统中玄参提取物对小鼠乳腺癌 4T1 细胞的生长抑制作用。
Biomed Pharmacother. 2017 Jan;85:718-724. doi: 10.1016/j.biopha.2016.11.086. Epub 2016 Dec 4.
4
In vitro anticancer activity of extracts on MCF-7 and WEHI-164 cell line.提取物对MCF-7和WEHI-164细胞系的体外抗癌活性。
EXCLI J. 2020 Sep 22;19:1341-1352. doi: 10.17179/excli2020-2737. eCollection 2020.
5
Effects of Urtica dioica dichloromethane extract on cell apoptosis and related gene expression in human breast cancer cell line (MDA-MB-468).荨麻二氯甲烷提取物对人乳腺癌细胞系（MDA-MB-468）细胞凋亡及相关基因表达的影响。
Cell Mol Biol (Noisy-le-grand). 2016 Feb 29;62(2):62-7.
6
Cytotoxic and Apoptotic Effects of Dumort Extract on MCF-7 Breast Cancer and 3T3 Cells.杜莫提取物对MCF-7乳腺癌细胞和3T3细胞的细胞毒性及凋亡作用。
Rep Biochem Mol Biol. 2019 Apr;8(1):79-84.
7
The Cytotoxic and Apoptotic Effects of Extracts on Human Breast Cancer Cells.提取物对人乳腺癌细胞的细胞毒性和凋亡作用。
Adv Pharm Bull. 2017 Sep;7(3):381-389. doi: 10.15171/apb.2017.046. Epub 2017 Sep 25.
8
Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line.尖萼玄参甲醇亚组分对人乳腺癌细胞系的细胞毒性和凋亡活性
Evid Based Complement Alternat Med. 2016;2016:8540640. doi: 10.1155/2016/8540640. Epub 2016 Feb 29.
9
Induction of Apoptosis and Cytotoxic Activities of Iranian Orthodox Black Tea Extract (BTE) Using in vitro Models.利用体外模型诱导伊朗传统红茶提取物（BTE）的细胞凋亡及细胞毒活性
Adv Pharm Bull. 2014;4(3):255-60. doi: 10.5681/apb.2014.037. Epub 2014 Feb 7.
10
Scrophularia Atropatana Extract Reverses TP53 Gene Promoter Hypermethylation and Decreases Survivin Antiapoptotic Gene Expression in Breast Cancer Cells.阿特洛帕提纳玄参提取物可逆转乳腺癌细胞中TP53基因启动子的高甲基化并降低生存素抗凋亡基因的表达。
Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2599-2605. doi: 10.22034/APJCP.2018.19.9.2599.

引用本文的文献

1
Effects of Methanolic Extract on Early Stages of Dimethylhydrazine-Induced Colon Carcinoma in Rats: Apoptosis Pathway Approach.甲醇提取物对二甲基肼诱导的大鼠结肠癌早期阶段的影响：凋亡途径研究
Adv Pharm Bull. 2022 Aug;12(4):835-841. doi: 10.34172/apb.2022.085. Epub 2021 Sep 29.
2
Anti-Proliferative and Anti-Biofilm Potentials of Bacteriocins Produced by Non-Pathogenic Enterococcus sp.非致病性肠球菌产生的细菌素的抗增殖和抗生物膜潜力
Probiotics Antimicrob Proteins. 2021 Apr;13(2):571-585. doi: 10.1007/s12602-020-09711-1. Epub 2020 Oct 3.
3
Phytochemical Analysis and Various Biological Activities of the Aerial Parts of Growing in Iran.伊朗生长的[植物名称未给出]地上部分的植物化学分析及多种生物活性
Iran J Pharm Res. 2019 Summer;18(3):1543-1555. doi: 10.22037/ijpr.2019.1100782.
4
Coss and Durieu: Phytochemical Composition and Biological Activities.科丝和迪尤：植物化学成分与生物活性。
Molecules. 2020 Apr 3;25(7):1647. doi: 10.3390/molecules25071647.
5
Cytotoxic and Apoptotic Effects of Dumort Extract on MCF-7 Breast Cancer and 3T3 Cells.杜莫提取物对MCF-7乳腺癌细胞和3T3细胞的细胞毒性及凋亡作用。
Rep Biochem Mol Biol. 2019 Apr;8(1):79-84.
6
The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity.玄参属植物：具有多种生物活性的环烯醚萜类和萜类化合物的来源。
Pharm Biol. 2017 Dec;55(1):2211-2233. doi: 10.1080/13880209.2017.1397178.
7
The Cytotoxic and Apoptotic Effects of Extracts on Human Breast Cancer Cells.提取物对人乳腺癌细胞的细胞毒性和凋亡作用。
Adv Pharm Bull. 2017 Sep;7(3):381-389. doi: 10.15171/apb.2017.046. Epub 2017 Sep 25.
8
Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line.尖萼玄参甲醇亚组分对人乳腺癌细胞系的细胞毒性和凋亡活性
Evid Based Complement Alternat Med. 2016;2016:8540640. doi: 10.1155/2016/8540640. Epub 2016 Feb 29.
9
Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.玄参提取物的二氯甲烷馏分诱导MCF-7人乳腺癌细胞凋亡。
Bosn J Basic Med Sci. 2015 Jan 29;15(1):26-32. doi: 10.17305/bjbms.2015.1.226.
10
Reduced ABCB1 Expression and Activity in the Presence of Acrylic Copolymers.在丙烯酸共聚物存在下ABCB1表达和活性降低。
Adv Pharm Bull. 2014;4(3):219-24. doi: 10.5681/apb.2014.032. Epub 2014 Feb 7.

本文引用的文献

1
Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321).玄参提取物对人星形细胞瘤细胞系（1321）抗癌特性的研究
Iran J Pharm Res. 2010 Fall;9(4):403-10.
2
Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells.柏木香脂素诱导乳腺癌细胞周期停滞、凋亡和自噬。
PLoS One. 2011;6(9):e24537. doi: 10.1371/journal.pone.0024537. Epub 2011 Sep 15.
3
Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.丹蒽醌，一种蒽醌衍生物，通过线粒体通透性转换孔和 Bax 触发的途径诱导 SNU-1 人胃癌细胞的 DNA 损伤和半胱天冬酶级联介导的细胞凋亡。
Chem Res Toxicol. 2011 Jan 14;24(1):20-9. doi: 10.1021/tx100248s. Epub 2010 Dec 2.
4
Flavonoids, cinnamic acid and phenyl propanoid from aerial parts of Scrophularia striata.玄参地上部分的类黄酮、肉桂酸和苯丙素。
Pharm Biol. 2010 Mar;48(3):333-6. doi: 10.3109/13880200903133829.
5
Cancer statistics, 2010.癌症统计数据，2010 年。
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
6
A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax.一种来自三叶青的天然化合物通过上调 Bax 诱导 MCF-7 细胞凋亡。
Cancer Cell Int. 2010 May 4;10:14. doi: 10.1186/1475-2867-10-14.
7
Induction of programmed cell death by Prangos uloptera, a medicinal plant.小白蒿诱导程序性细胞死亡。
Biol Res. 2009;42(4):517-22. Epub 2010 Jan 29.
8
Cytotoxic effects of bangladeshi medicinal plant extracts.孟加拉药用植物提取物的细胞毒性作用。
Evid Based Complement Alternat Med. 2011;2011:578092. doi: 10.1093/ecam/nep111. Epub 2011 Jan 12.
9
Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism.鳄梨提取物通过活性氧介导的机制选择性诱导人口腔癌细胞系凋亡。
Nutr Cancer. 2009;61(3):348-56. doi: 10.1080/01635580802567158.
10
Apoptosis and non-apoptotic deaths in cancer development and treatment response.癌症发生发展及治疗反应中的细胞凋亡与非凋亡性死亡
Cancer Treat Rev. 2008 Dec;34(8):737-49. doi: 10.1016/j.ctrv.2008.07.001. Epub 2008 Aug 22.

尖萼玄参的二氯甲烷和甲醇提取物诱导MCF-7人乳腺癌细胞凋亡。

Dichloromethane and Methanol Extracts of Scrophularia oxysepala Induces Apoptosis in MCF-7 Human Breast Cancer Cells.

作者信息

Valiyari Samira, Baradaran Behzad, Delazar Abbas, Pasdaran Ardalan, Zare Fateme

机构信息

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ; Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Adv Pharm Bull. 2012;2(2):223-31. doi: 10.5681/apb.2012.034. Epub 2012 Aug 15.

DOI:10.5681/apb.2012.034
PMID:24312797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3845997/
Abstract

PURPOSE

Breast cancer is the most common cause of cancer-related death in women worldwide. Therefore, there is an urgent need to identify and develop therapeutic strategies against this deadly disease. This study is the first to investigate the cytotoxic effects and the mechanism of cell death of Scrophularia oxysepala extracts in MCF-7 human breast cancer cells.

METHODS

Three extracts of Scrophularia oxysepala including the n-hexane, dichloromethane and methanol extracts were examined. MTT (3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and Trypan-blue assays were performed in MCF-7 cells as well as Human umbilical vein endothelial cells (HUVEC) to analyze the cytotoxic activity of the extracts of Scrophularia oxysepala. Further, the apoptosis inducing action of the extracts was determined by TUNEL (terminal deoxy transferase (TdT)-mediated dUTP nick- end labeling) test and cell death assay.

RESULTS

The results showed that the n-hexane extract had no cytotoxic effects but dichloromethane and methanol extracts significantly inhibited cell growth and viability in a dose and time dependent manner without inducing damage to non-cancerous cell line HUVEC. In addition, Cell death assay and DNA fragmentation analysis using TUNEL indicated induction of apoptosis by dichloromethane and methanol extracts of Scrophularia oxysepala in MCF-7 cells.

CONCLUSION

Our studies suggest that this plant may contain potential bioactive compound(s) for the treatment of breast cancer.

摘要

目的

乳腺癌是全球女性癌症相关死亡的最常见原因。因此，迫切需要确定并开发针对这种致命疾病的治疗策略。本研究首次调查玄参提取物对MCF-7人乳腺癌细胞的细胞毒性作用及细胞死亡机制。

方法

检测了玄参的三种提取物，包括正己烷提取物、二氯甲烷提取物和甲醇提取物。在MCF-7细胞以及人脐静脉内皮细胞（HUVEC）中进行MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐）和台盼蓝试验，以分析玄参提取物的细胞毒性活性。此外，通过TUNEL（末端脱氧转移酶介导的dUTP缺口末端标记）试验和细胞死亡试验确定提取物的凋亡诱导作用。

结果

结果表明，正己烷提取物无细胞毒性作用，但二氯甲烷和甲醇提取物以剂量和时间依赖性方式显著抑制细胞生长和活力，且不损伤非癌细胞系HUVEC。此外，细胞死亡试验和使用TUNEL的DNA片段化分析表明，玄参的二氯甲烷和甲醇提取物可诱导MCF-7细胞凋亡。

结论

我们的研究表明，这种植物可能含有治疗乳腺癌的潜在生物活性化合物。