人乳头瘤病毒 33 型的全球遗传变异与宫颈癌的发病风险。
Human papillomavirus 33 worldwide genetic variation and associated risk of cervical cancer.
机构信息
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France.
出版信息
Virology. 2014 Jan 5;448:356-62. doi: 10.1016/j.virol.2013.10.033. Epub 2013 Nov 12.
Abstract
Human papillomavirus (HPV) 33, a member of the HPV16-related alpha-9 species group, is found in approximately 5% of cervical cancers worldwide. The current study aimed to characterize the genetic diversity of HPV33 and to explore the association of HPV33 variants with the risk for cervical cancer. Taking advantage of the International Agency for Research on Cancer biobank, we sequenced the entire E6 and E7 open reading frames of 213 HPV33-positive cervical samples from 30 countries. We identified 28 HPV33 variants that formed 5 phylogenetic groups: the previously identified A1, A2, and B (sub)lineages and the novel A3 and C (sub)lineages. The A1 sublineage was strongly over-represented in cervical cases compared to controls in both Africa and Europe. In conclusion, we provide a classification system for HPV33 variants based on the sequence of E6 and E7 and suggest that the association of HPV33 with cervical cancer may differ by variant (sub)lineage.
摘要
人乳头瘤病毒（HPV）33 是 HPV16 相关的α-9 种组群的一个成员，在全球约 5%的宫颈癌中被发现。本研究旨在描述 HPV33 的遗传多样性，并探索 HPV33 变体与宫颈癌风险之间的关联。利用国际癌症研究机构生物银行，我们对来自 30 个国家的 213 个 HPV33 阳性宫颈样本的整个 E6 和 E7 开放阅读框进行了测序。我们鉴定了 28 种 HPV33 变体，它们形成了 5 个系统发育群：先前鉴定的 A1、A2 和 B（亚）谱系，以及新的 A3 和 C（亚）谱系。与对照相比，A1 亚谱系在非洲和欧洲的宫颈癌病例中明显过多。总之，我们提供了一种基于 E6 和 E7 序列的 HPV33 变体分类系统，并提出 HPV33 与宫颈癌的关联可能因变体（亚）谱系而异。
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