Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Cell. 2013 Dec 5;155(6):1216-9. doi: 10.1016/j.cell.2013.11.019.
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
癌症的小鼠模型揭示了自噬在促进癌症方面的新作用。自噬通过抑制 p53 反应、维持线粒体功能、维持代谢平衡和在应激中存活以及防止肿瘤进展为良性肾嗜酸细胞瘤,从而促进肿瘤生长。