Wilson Sally, Bremner Alexandra P, Mathews Judy, Pearson Diane
Princess Margaret Hospital for Children, Child and Adolescent Health Service, Perth, Western Australia; School of Nursing and Midwifery, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth, Western Australia.
School of Population Health, The University of Western Australia, Perth, Western Australia.
Pain Manag Nurs. 2013 Dec;14(4):e95-e105. doi: 10.1016/j.pmn.2011.08.002. Epub 2012 Jan 9.
The aim of this study was to evaluate the effectiveness of oral sucrose in decreasing pain during minor procedures in infants of 1-6 months corrected age. A blinded randomized controlled trial with infants aged 4-26 weeks who underwent venipuncture, heel lance or intravenous cannulation were stratified by corrected age into > 4-12 weeks and > 12-26 weeks. They received 2 mL of either 25% sucrose or sterile water orally 2 minutes before the painful procedure. Nonnutritional sucking and parental comfort, provided in adherence to hospital guidelines, were recorded. Pain behavior was recorded using a validated 10 point scale at baseline, during and following the procedure. Data collectors were blinded to the intervention. A total of 21 and 20 infants received sucrose and water, respectively, in the > 4-12-week age group, and 21 and 22, respectively, in the > 12-26-week age group. No statistical differences were found in pain scores between treatment and control groups at any data collection points in either age group. Infants aged > 4-12 weeks who did nonnutritional sucking showed statistically significantly lower median pain scores at 1, 2, and 3 minutes after the procedure than those who did not suck. Infants aged > 4-26 weeks exhibited pain behavior scores that indicated moderate to large pain during painful procedures; however, there was insufficient evidence to show that 2 mL 25% sucrose had a statistically significant effect in decreasing pain. Infants should be offered nonnutritional sucking in compliance with the Baby Friendly Health Initiative during painful procedures.
本研究的目的是评估口服蔗糖在减轻1至6个月矫正年龄婴儿进行小手术时疼痛方面的有效性。一项针对4至26周龄接受静脉穿刺、足跟采血或静脉插管的婴儿的双盲随机对照试验，根据矫正年龄分层为>4至12周和>12至26周。在进行疼痛手术前2分钟，他们口服2毫升25%蔗糖溶液或无菌水。记录了按照医院指南提供的非营养性吸吮和父母安抚情况。在基线、手术期间和手术后，使用经过验证的10分制量表记录疼痛行为。数据收集者对干预措施不知情。在>4至12周龄组中，分别有21名和20名婴儿接受了蔗糖和水；在>12至26周龄组中，分别有21名和22名婴儿接受了蔗糖和水。在两个年龄组的任何数据收集点，治疗组和对照组之间的疼痛评分均未发现统计学差异。在>4至12周龄且进行了非营养性吸吮的婴儿中，术后1分钟、2分钟和3分钟的中位疼痛评分在统计学上显著低于未吸吮的婴儿。年龄在>4至26周的婴儿在疼痛手术期间表现出的疼痛行为评分表明存在中度至重度疼痛；然而，没有足够的证据表明2毫升25%蔗糖溶液在减轻疼痛方面具有统计学显著效果。在疼痛手术期间，应按照“爱婴医院倡议”为婴儿提供非营养性吸吮。
