Haouari N, Wood C, Griffiths G, Levene M
University Division of Paediatrics and Child Health, Leeds General Infirmary.
BMJ. 1995 Jun 10;310(6993):1498-500. doi: 10.1136/bmj.310.6993.1498.
To evaluate the effects of different sucrose concentrations on measures of neonatal pain.
Randomised, double blind, placebo controlled trial of sterile water (control) or one of three solutions of sucrose--namely, 12.5%, 25%, and 50% wt/vol.
Postnatal ward.
60 healthy infants of gestational age 37-42 weeks and postnatal age 1-6 days randomised to receive 2 ml of one of the four solutions on to the tongue two minutes before heel prick sampling for serum bilirubin concentrations.
Duration of crying over the first three minutes after heel prick.
There was a significant reduction in overall crying time and heart rate after three minutes in the babies given 50% sucrose as compared with controls. This was maximal one minute after heel prick in the 50% sucrose group and became statistically significant in the 25% sucrose group at two minutes. There was a significant trend for a reduction in crying time with increasing concentrations of sucrose over the first three minutes.
Concentrated sucrose solution seems to reduce crying and the autonomic effects of a painful procedure in healthy normal babies. Sucrose may be a useful and safe analgesic for minor procedures in neonates.
评估不同蔗糖浓度对新生儿疼痛指标的影响。
对无菌水（对照）或三种蔗糖溶液（即12.5%、25%和50%重量/体积）之一进行随机、双盲、安慰剂对照试验。
产后病房。
60名胎龄37 - 42周、出生后1 - 6天的健康婴儿，随机分组，在足跟采血检测血清胆红素浓度前两分钟，给其舌头上滴入2毫升四种溶液中的一种。
足跟采血后前三分钟的哭闹持续时间。
与对照组相比，给予50%蔗糖的婴儿在三分钟后的总体哭闹时间和心率显著降低。在50%蔗糖组中，足跟采血后一分钟时这种效果最为明显，在25%蔗糖组中两分钟时具有统计学意义。在前三分钟内，随着蔗糖浓度增加，哭闹时间有显著减少的趋势。
浓缩蔗糖溶液似乎能减少健康正常婴儿的哭闹以及疼痛操作引起的自主神经反应。蔗糖可能是新生儿小手术中一种有用且安全的镇痛药。
