Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
J Trace Elem Med Biol. 2014 Jan;28(1):56-9. doi: 10.1016/j.jtemb.2013.11.003. Epub 2013 Nov 23.
To determine whether blood lead concentration is elevated in iron-deficient infants, blood lead and serum ferritin concentrations, serum iron/transferring iron-binding capacity (Fe/TIBC) and complete blood counts were measured in 30 iron deficient and 35 control infants, aged 6-24 months. All 30 iron-deficient infants received iron supplementation (ferric hydroxide-polymaltose complex, 6mg/kg Fe(3+)/day) for 1-6 months. Blood lead concentrations were measured in 18 of the iron deficient infants after their ferritin levels returned to the normal range. The geometric mean blood lead concentration was higher in iron deficient than in control infants (1.846 vs. 1.416μg/dL). After iron therapy, the blood lead levels of iron-deficient infants decreased significantly compared with pre-treatment levels (1.785 vs. 2.386μg/dL), and the hemoglobin and ferritin concentrations increased significantly. These findings indicate that iron deficiency increases blood lead concentrations in infants with very low blood lead concentrations.
为了确定缺铁的婴儿是否血铅浓度升高，我们测量了 30 名缺铁和 35 名对照婴儿（6-24 个月）的血铅和血清铁蛋白浓度、血清铁/转铁蛋白结合能力（Fe/TIBC）和全血细胞计数。所有 30 名缺铁婴儿均接受铁补充剂（三价铁-多聚麦芽糖复合物，每天 6mg/kg Fe(3+)）治疗 1-6 个月。在 18 名缺铁婴儿的铁蛋白水平恢复正常范围后，测量了他们的血铅浓度。缺铁组的血铅浓度几何平均值高于对照组（1.846 与 1.416μg/dL）。铁治疗后，与治疗前相比，缺铁婴儿的血铅水平显著下降（1.785 与 2.386μg/dL），血红蛋白和铁蛋白浓度显著升高。这些发现表明，在血铅浓度非常低的婴儿中，缺铁会增加血铅浓度。
