Park Sangkyu, Sim Chang-Sun, Lee Heun, Kim Yangho
Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Biol Trace Elem Res. 2013 Nov;155(2):184-9. doi: 10.1007/s12011-013-9782-9. Epub 2013 Aug 17.
The present study was done to determine whether blood Mn concentration is elevated in iron-deficient infants. Thirty-one infants with iron deficiency and thirty-six control subjects (6-24 months of age) were tested for blood Mn concentration, complete blood counts, serum ferritin, and serum iron/transferring iron-binding capacity (Fe/TIBC). All the 31 iron-deficient infants were treated with iron supplement; however, 19 of them underwent blood Mn checkup again in compliance with follow-up schedule when their ferritin levels returned to the normal range. Iron therapies were done for 1-6 months (mean, 2.8; standard deviation, 1.6) using ferric hydroxide-polymaltose complex (6 mg/kg Fe(3+) daily). Infants with iron deficiency had a higher mean blood Mn concentration than controls (2.550 vs. 1.499 μg/dL, respectively). After iron therapy, the blood Mn levels of iron-deficient infants significantly decreased compared to their pre-therapy levels (2.045 vs. 2.971 μg/dL, respectively), and their hemoglobin and ferritin levels significantly increased. After adjustment for covariates (e.g., age and breast-feeding), multiple linear regression models showed that increased blood Mn levels were significantly associated with low serum ferritin and hemoglobin levels, whereas with Fe/TIBC there was only a tendency. Our results indicate that iron deficiency increases blood Mn levels in infants, presumably by increasing Mn absorption.
本研究旨在确定缺铁婴儿的血液锰浓度是否升高。对31名缺铁婴儿和36名对照受试者（6至24个月大）进行了血液锰浓度、全血细胞计数、血清铁蛋白以及血清铁/转铁蛋白铁结合能力（Fe/TIBC）检测。所有31名缺铁婴儿均接受了铁补充剂治疗；然而，其中19名婴儿在其铁蛋白水平恢复到正常范围时，按照随访计划再次进行了血液锰检查。使用氢氧化铁-聚麦芽糖复合物（每日6 mg/kg Fe(3+)）进行铁疗法1至6个月（平均2.8个月；标准差1.6个月）。缺铁婴儿的平均血液锰浓度高于对照组（分别为2.550 μg/dL和1.499 μg/dL）。铁疗法后，缺铁婴儿的血液锰水平与其治疗前水平相比显著降低（分别为2.045 μg/dL和2.971 μg/dL），且其血红蛋白和铁蛋白水平显著升高。在对协变量（如年龄和母乳喂养）进行调整后，多元线性回归模型显示，血液锰水平升高与低血清铁蛋白和血红蛋白水平显著相关，而与Fe/TIBC仅存在一种趋势。我们的结果表明，缺铁会增加婴儿的血液锰水平，可能是通过增加锰的吸收实现的。
