腹股沟疝修补术中的局部麻醉：右旋糖酐和盐溶液对布比卡因作用持续时间的影响。
Local anaesthesia in inguinal herniorrhaphy: influence of dextran and saline solutions on duration of action of bupivacaine.
作者信息
Armstrong D N, Kingsnorth A N
出版信息
Ann R Coll Surg Engl. 1986 Jul;68(4):207-8.
Abstract
Because recent clinical trials have shown that dextran solutions can prolong the local anaesthetic action of 0.25% bupivacaine, a prospective double blind trial was performed in patients (n = 50) undergoing uncomplicated elective inguinal herniorrhaphy under local anaesthesia alone. Patients were randomised prior to infiltration of local anaesthesia into 2 groups: 0.5% bupivacaine (30 ml) diluted with an equal volume of either 0.9% saline or an equal volume of dextran 110. There was no significant difference in duration nor degree of postoperative anaesthesia between the two groups. Dextran solutions were found to be significantly more acidic than saline solutions and the possible effects of this on bupivacaine kinetics are discussed.
摘要
由于近期临床试验表明葡聚糖溶液可延长0.25%布比卡因的局部麻醉作用，因此对仅接受局部麻醉的50例择期行无并发症腹股沟疝修补术患者进行了一项前瞻性双盲试验。在局部麻醉浸润前，将患者随机分为2组：0.5%布比卡因（30 ml）用等体积的0.9%生理盐水或等体积的右旋糖酐110稀释。两组术后麻醉持续时间和程度均无显著差异。发现葡聚糖溶液的酸性明显高于盐溶液，并讨论了其对布比卡因动力学可能产生的影响。
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A local-anaesthetic solution with longer action.一种作用时间更长的局部麻醉溶液。
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Prolonged local analgesia for inguinal herniorrhaphy with bupivacaine and dextran.布比卡因和右旋糖酐用于腹股沟疝修补术的长效局部镇痛
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Postoperative analgesia for thoracotomy patients.开胸手术患者的术后镇痛
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Studies on the duration of local anaesthesia: a possible mechanism for the prolonging effect of dextran on the duration of infiltration anaesthesia.局部麻醉持续时间的研究：右旋糖酐对浸润麻醉持续时间延长作用的一种可能机制。
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Evaluation of dextran with local anaesthesia for short-stay inguinal herniorraphy.右旋糖酐联合局部麻醉用于短期住院腹股沟疝修补术的评估。
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