Local anaesthesia in inguinal herniorrhaphy: influence of dextran and saline solutions on duration of action of bupivacaine.
作者信息
Armstrong D N, Kingsnorth A N
出版信息
Ann R Coll Surg Engl. 1986 Jul;68(4):207-8.
Abstract
Because recent clinical trials have shown that dextran solutions can prolong the local anaesthetic action of 0.25% bupivacaine, a prospective double blind trial was performed in patients (n = 50) undergoing uncomplicated elective inguinal herniorrhaphy under local anaesthesia alone. Patients were randomised prior to infiltration of local anaesthesia into 2 groups: 0.5% bupivacaine (30 ml) diluted with an equal volume of either 0.9% saline or an equal volume of dextran 110. There was no significant difference in duration nor degree of postoperative anaesthesia between the two groups. Dextran solutions were found to be significantly more acidic than saline solutions and the possible effects of this on bupivacaine kinetics are discussed.
摘要
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Prolonged local analgesia for inguinal herniorrhaphy with bupivacaine and dextran.布比卡因和右旋糖酐用于腹股沟疝修补术的长效局部镇痛
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