Kingsnorth A N, Wijesinha S S, Grixti C J
Ann R Coll Surg Engl. 1979 Nov;61(6):456-8.
A prospective randomised study of 40 patients undergoing unilateral inguinal herniorrhaphy under local anaesthesia was undertaken. Half the patients received the local anaesthetic (0.25% bupivacaine) mixed with dextran 40 solution. Subjective and objective assessments were made of the postoperative pain experienced in the first 48 h after operation. The use of 0.25% bupivacaine local inguinal block results in a postoperative pain-free period of approximately 10 h. Simple oral analgesics are adequate for postoperative pain relief in 87.5% of patients and are required relatively infrequently. The addition of dextran 40 to the local anaesthetic has no significant effect on its duration of action.
对40例在局部麻醉下接受单侧腹股沟疝修补术的患者进行了一项前瞻性随机研究。一半患者接受与右旋糖酐40溶液混合的局部麻醉剂(0.25%布比卡因)。对术后48小时内经历的术后疼痛进行了主观和客观评估。使用0.25%布比卡因局部腹股沟阻滞可产生约10小时的术后无痛期。简单的口服镇痛药足以缓解87.5%患者的术后疼痛,且使用频率相对较低。在局部麻醉剂中添加右旋糖酐40对其作用持续时间无显著影响。