Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1HH, UK.
Nucleic Acids Res. 2014 Jan;42(Database issue):D771-9. doi: 10.1093/nar/gkt1241. Epub 2013 Dec 6.
The Vertebrate Genome Annotation (VEGA) database (http://vega.sanger.ac.uk), initially designed as a community resource for browsing manual annotation of the human genome project, now contains five reference genomes (human, mouse, zebrafish, pig and rat). Its introduction pages have been redesigned to enable the user to easily navigate between whole genomes and smaller multi-species haplotypic regions of interest such as the major histocompatibility complex. The VEGA browser is unique in that annotation is updated via the Human And Vertebrate Analysis aNd Annotation (HAVANA) update track every 2 weeks, allowing single gene updates to be made publicly available to the research community quickly. The user can now access different haplotypic subregions more easily, such as those from the non-obese diabetic mouse, and display them in a more intuitive way using the comparative tools. We also highlight how the user can browse manually annotated updated patches from the Genome Reference Consortium (GRC).
脊椎动物基因组注释（VEGA）数据库（http://vega.sanger.ac.uk）最初是作为浏览人类基因组计划手动注释的社区资源而设计的，现在包含了五个参考基因组（人类、小鼠、斑马鱼、猪和大鼠）。其介绍页面已重新设计，使用户能够轻松在整个基因组和较小的多物种感兴趣的单倍型区域之间进行导航，例如主要组织相容性复合体。VEGA 浏览器的独特之处在于，通过每两周更新一次人类和脊椎动物分析及注释（HAVANA）更新轨道来更新注释，允许快速将单个基因更新公开提供给研究社区。用户现在可以更轻松地访问不同的单倍型亚区，例如非肥胖型糖尿病小鼠的亚区，并使用比较工具更直观地显示它们。我们还强调了用户如何浏览基因组参考联盟（GRC）的手动注释更新补丁。
