一个 METTL3-METTL14 复合物介导了哺乳动物核 RNA N6-腺苷酸甲基化。
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
机构信息
1] Department of Chemistry, University of Chicago, Chicago, Illinois, USA. [2] Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA. [3].
1] Department of Chemistry, University of Chicago, Chicago, Illinois, USA. [2] Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA.
出版信息
Nat Chem Biol. 2014 Feb;10(2):93-5. doi: 10.1038/nchembio.1432. Epub 2013 Dec 6.
N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m(6)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
N(6)-甲基腺嘌呤（m(6)A）是哺乳动物信使 RNA 和非编码 RNA 中最普遍和最可逆转的内部修饰。我们在此报告，人类甲基转移酶样蛋白 14（METTL14）催化 m(6)A RNA 甲基化。与之前唯一已知的 m(6)A 甲基转移酶 METTL3 一起，这两种蛋白形成了 METTL3-METTL14 的稳定异二聚体核心复合物，在哺乳动物核 RNA 上发挥细胞内 m(6)A 沉积的功能。WTAP，一种哺乳动物剪接因子，可与该复合物相互作用并影响该甲基化。
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