一种通过使用携带荧光氨基酸的 tRNA 进行体外选择而开发的荧光肽探针。
A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid.
机构信息
Nano Medical Engineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
出版信息
Chem Commun (Camb). 2014 Mar 18;50(22):2962-4. doi: 10.1039/c3cc47624c. Epub 2013 Dec 9.
PMID:24317094
Abstract
A peptide that binds and emits fluorescence in response to conformational change in a target protein was developed by in vitro selection using tRNA carrying a fluorogenic amino acid. This technology could prove to be useful for the development of separation-free immunoassays and bio-imaging analyses.
摘要
通过使用携带荧光氨基酸的 tRNA 进行体外选择，开发出一种可与靶蛋白构象变化结合并发出荧光的肽。这项技术有望用于开发无需分离的免疫分析和生物成像分析。
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