早期胃癌中的DNA分布模式。胃刷片的福尔根细胞光度学研究。

DNA distribution patterns in early gastric carcinomas. A Feulgen cytometric study of gastric brush smears.

作者信息

Czerniak B, Herz F, Koss L G

出版信息

Cancer. 1987 Jan 1;59(1):113-7. doi: 10.1002/1097-0142(19870101)59:1<113::aid-cncr2820590124>3.0.co;2-1.

DOI:10.1002/1097-0142(19870101)59:1<113::aid-cncr2820590124>3.0.co;2-1

Abstract

DNA distribution patterns were studied by cytophotometry in 20 Feulgen-stained brush smears of early gastric carcinomas. Two different DNA distribution patterns, classified as predominantly diploid and aneuploid, were correlated with histologic data. Six of seven carcinomas of diffuse type were predominantly diploid. By contrast, 11 of 13 intestinal type carcinomas were aneuploid and two were diploid. Since the DNA distribution patterns recorded in this study were previously observed in advanced gastric carcinomas, this would suggest that the basic genetic make-up of the tumors does not change with tumor progression.

摘要

通过细胞光度测定法对20例早期胃癌的福尔根染色刷片涂片进行了DNA分布模式研究。两种不同的DNA分布模式，分为主要为二倍体和非整倍体，与组织学数据相关。7例弥漫型癌中有6例主要为二倍体。相比之下，13例肠型癌中有11例为非整倍体，2例为二倍体。由于本研究中记录的DNA分布模式先前在进展期胃癌中也观察到，这表明肿瘤的基本基因组成不会随肿瘤进展而改变。