在体外受精治疗中，卵巢敏感性指数比卵母细胞数量更能准确衡量卵巢对促性腺激素刺激的反应。
Ovarian sensitivity index is a better measure of ovarian responsiveness to gonadotrophin stimulation than the number of oocytes during in-vitro fertilization treatment.
作者信息
Li Hang Wun Raymond, Lee Vivian Chi Yan, Ho Pak Chung, Ng Ernest Hung Yu
机构信息
Centre of Assisted Reproduction and Embryology, Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong,
出版信息
J Assist Reprod Genet. 2014 Feb;31(2):199-203. doi: 10.1007/s10815-013-0144-5. Epub 2013 Dec 8.
Abstract
PURPOSE
To validate the use of the ovarian sensitivity index (OSI) as a measure of ovarian response during in-vitro fertilization (IVF) treatment.
METHODS
This is a retrospective study carried out in an assisted reproduction unit in a teaching hospital. We analysed data from 2,556 women undergoing the first IVF cycle between 2002 and 2009. OSI was calculated as the number of retrieved oocytes divided by total dose of FSH administered (per 1,000 IU). Its correlation to other parameters of ovarian response was compared to that of the oocyte number.
RESULTS
The correlation coefficients of OSI with age, AFC, AMH, total dose of gonadotrophin, average daily dose of gonadotrophin and duration of stimulation were significantly higher than that of oocyte number with these respective parameters. OSI demonstrated a higher intraclass correlation coefficient (ICC) than the oocyte number when comparing the two parameters across the first and second stimulated IVF cycles.
CONCLUSIONS
OSI is a better measure of ovarian responsiveness to gonadotrophin stimulation than the oocyte number, and is particularly useful when different subjects are treated with different stimulation regimens which would have confounding effect on the oocyte number.
摘要
目的
验证卵巢敏感性指数（OSI）作为体外受精（IVF）治疗期间卵巢反应指标的应用价值。
方法
这是一项在教学医院的辅助生殖单元进行的回顾性研究。我们分析了2002年至2009年间接受首次IVF周期治疗的2556名女性的数据。OSI的计算方法为回收的卵母细胞数除以促卵泡激素（FSH）的总给药剂量（每1000国际单位）。将其与卵巢反应的其他参数的相关性与卵母细胞数的相关性进行比较。
结果
OSI与年龄、窦卵泡计数（AFC）、抗缪勒管激素（AMH）、促性腺激素总剂量、促性腺激素平均每日剂量和刺激持续时间的相关系数显著高于卵母细胞数与这些相应参数的相关系数。在比较首次和第二次刺激IVF周期的两个参数时，OSI显示出比卵母细胞数更高的组内相关系数（ICC）。
结论
与卵母细胞数相比，OSI是评估卵巢对促性腺激素刺激反应性的更好指标，当不同受试者接受不同刺激方案治疗时尤其有用，因为不同刺激方案会对卵母细胞数产生混杂影响。
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