Aono Koji, Miyashita Shotaro, Fujiwara Yosuke, Kodama Mitsuhiko, Hanayama Kozo, Masakado Yoshihisa, Ushiba Junichi
Department of Rehabilitation Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Tokai J Exp Clin Med. 2013 Dec 20;38(4):123-8.
Relation between cortical excitability and magnitudes of event-related dysynchronizaton (ERD) has not been clarified. This study was investigated that relationshp between cortical excitability and ERD magnitudes in healthy subjects and stroke patients.
Ten healthy subjects and four patients with stroke participated in this study. EEGs were recorded over the sensorimotor cortex (left hemisphere in healthy subjects; damaged hemisphere in stroke subjects) to calculate ERD during motor imagery,. Motor-evoked potential (MEP) induced by single-pulse transcranial magnetic stimulation over the primary motor cortex was recorded from the first dorsal interosseus (FDI) muscle at ERD magnitudes of 10% and 30%.
MEP significantly increased at 10% and 30% ERD (p<0.01) than that during rest in healthy subjects. The 30% ERD condition showed significantly higher MEP than that at 10% ERD (p<0.05). In stroke patients, MEP increased with ERD induced by motor imagery, but the change of MEP to ERD amplitude was critically different among the subject.
ERD magnitude corresponds to corticospinal excitability increases in healthy subjects and patients with hemiplegic stroke. BCI based on motor imagery-induced ERD may be a potential rehabilitation strategy for patients with hemiplegic stroke.
皮层兴奋性与事件相关去同步化（ERD）幅度之间的关系尚未明确。本研究旨在调查健康受试者和中风患者中皮层兴奋性与ERD幅度之间的关系。
10名健康受试者和4名中风患者参与了本研究。在运动想象期间，记录感觉运动皮层（健康受试者为左半球；中风受试者为受损半球）的脑电图以计算ERD。在ERD幅度为10%和30%时，从第一背侧骨间肌（FDI）记录由单脉冲经颅磁刺激初级运动皮层诱发的运动诱发电位（MEP）。
与健康受试者休息时相比，在ERD为10%和30%时MEP显著增加（p<0.01）。30%ERD条件下的MEP显著高于10%ERD时的MEP（p<0.05）。在中风患者中，MEP随运动想象诱发的ERD增加，但不同受试者中MEP对ERD幅度的变化差异很大。
在健康受试者和偏瘫中风患者中，ERD幅度与皮质脊髓兴奋性增加相对应。基于运动想象诱发的ERD的脑机接口可能是偏瘫中风患者的一种潜在康复策略。
