Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, 12 Mid-Wulumuqi Road, Jing'an District, Shanghai, 200040, China.
School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Biomed Eng Online. 2023 Apr 15;22(1):36. doi: 10.1186/s12938-023-01091-1.
Brain-computer interfaces (BCIs) are emerging as a promising tool for upper limb recovery after stroke, and motor tasks are an essential part of BCIs for patient training and control of rehabilitative/assistive BCIs. However, the correlation between brain activation with different levels of motor impairment and motor tasks in BCIs is still not so clear. Thus, we aim to compare the brain activation of different levels of motor impairment in performing the hand grasping and opening tasks in BCIs.
We instructed stroke patients to perform motor attempts (MA) to grasp and open the affected hand for 30 trials, respectively. During this period, they underwent EEG acquisition and BCIs accuracy recordings. They also received detailed history records and behavioral scale assessments (the Fugl-Meyer assessment of upper limb, FMA-UE).
The FMA-UE was negatively correlated with the event-related desynchronization (ERD) of the affected hemisphere during open MA (R = - 0.423, P = 0.009) but not with grasp MA (R = - 0.058, P = 0.733). Then we divided the stroke patients into group 1 (Brunnstrom recovery stages between I to II, n = 19) and group 2 (Brunnstrom recovery stages between III to VI, n = 23). No difference during the grasping task (t = 0.091, P = 0.928), but a significant difference during the open task (t = 2.156, P = 0.037) was found between the two groups on the affected hemisphere. No significant difference was found in the unaffected hemisphere.
The study indicated that brain activation is positively correlated with the hand function of stroke in open-hand tasks. In the grasping task, the patients in the different groups have a similar brain response, while in the open task, mildly injured patients have more brain activation in open the hand than the poor hand function patients.
脑机接口（BCIs）作为中风后上肢康复的一种有前途的工具正在出现，运动任务是 BCI 用于患者训练和控制康复/辅助 BCI 的重要组成部分。然而，不同运动障碍水平的大脑激活与 BCI 中的运动任务之间的相关性尚不清楚。因此，我们旨在比较在执行手部抓握和张开任务时不同运动障碍水平的大脑激活。
我们指导中风患者进行 30 次尝试，分别用患手进行抓握和张开运动。在此期间，他们接受了 EEG 采集和 BCI 准确性记录。他们还接受了详细的病史记录和行为量表评估（上肢 Fugl-Meyer 评估，FMA-UE）。
FMA-UE 与张开 MA 时患侧半球的事件相关去同步（ERD）呈负相关（R=-0.423，P=0.009），但与抓握 MA 无关（R=-0.058，P=0.733）。然后我们将中风患者分为 1 组（Brunnstrom 恢复阶段 I 至 II 期，n=19）和 2 组（Brunnstrom 恢复阶段 III 至 VI 期，n=23）。在抓握任务中没有差异（t=0.091，P=0.928），但在张开任务中两组之间存在显著差异（t=2.156，P=0.037），患侧半球。在非患侧半球未发现显著差异。
研究表明，大脑激活与中风患者张开手任务的手部功能呈正相关。在抓握任务中，不同组的患者具有相似的大脑反应，而在张开任务中，手部功能较差的患者张开手的大脑激活程度高于手部功能较差的患者。
