Tomlinson D R, Willars G B, Robinson J P
Drugs. 1986;32 Suppl 2:15-8. doi: 10.2165/00003495-198600322-00005.
Experiments on streptozotocin-diabetic rats have indicated that axonal transport of choline acetyltransferase is reduced in sciatic nerve. Treatment with an aldose reductase inhibitor both prevented and reversed this defect which was related to marked accumulations of sorbitol and fructose. Concurrent with these accumulations the content of myo-inositol in diabetic peripheral nerve is depleted. Further experiments taking account of nerve water content showed that the depletion of myo-inositol was 'real' not apparent. When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented.
对链脲佐菌素诱导的糖尿病大鼠进行的实验表明，坐骨神经中胆碱乙酰转移酶的轴突运输减少。用醛糖还原酶抑制剂治疗可预防并逆转这一缺陷，该缺陷与山梨醇和果糖的显著积累有关。伴随着这些积累，糖尿病周围神经中肌醇的含量减少。考虑到神经含水量的进一步实验表明，肌醇的减少是“真实的”而非表观的。当通过喂食肌醇或抑制醛糖还原酶来维持肌醇水平时，胆碱乙酰转移酶和含胆碱脂质的轴突运输缺陷的发展得到了预防。
