a Department of Cancer Experiences Research , Peter MacCallum Cancer Centre , Melbourne , Australia.
Nutr Cancer. 2014;66(1):47-56. doi: 10.1080/01635581.2014.847966. Epub 2013 Dec 9.
The prevalence of malnutrition in lung cancer patients across a variety of treatment modalities and disease stages ranges from 45% to 69%. Malnutrition is associated with poorer clinical outcomes in cancer patients. This systematic review examined whether dietary counseling or oral supplements during chemotherapy and/or radiotherapy in patients with lung cancer affect patient or clinical outcomes. Relevant nutrition intervention studies from 1980 to March 2012 were identified. Articles meeting predetermined inclusion/exclusion criteria were critically appraised and included in the review. The outcomes of interest included dietary intake, weight, nutritional status, quality of life, functional status, treatment response, and survival. Five eligible studies were identified including 3 randomized controlled trials, 1 historical cohort, and 1 case series. These studies suggest dietary counseling improves energy and protein intake during chemotherapy in patients with lung cancer but has no benefit to other outcomes during chemotherapy. There is insufficient evidence regarding the effect on patient or clinical outcomes during radiotherapy. Randomized trials examining dietary counseling in patients with lung cancer during radiotherapy are required.
在各种治疗方式和疾病阶段的肺癌患者中，营养不良的患病率从 45%到 69%不等。营养不良与癌症患者的临床预后较差有关。本系统评价研究了肺癌患者在化疗和/或放疗期间接受饮食咨询或口服补充剂是否会影响患者或临床结局。从 1980 年到 2012 年 3 月确定了相关的营养干预研究。符合预定纳入/排除标准的文章进行了严格评价，并纳入了综述。感兴趣的结局包括饮食摄入、体重、营养状况、生活质量、功能状态、治疗反应和生存。确定了 5 项合格的研究，包括 3 项随机对照试验、1 项历史队列研究和 1 项病例系列研究。这些研究表明，饮食咨询可改善肺癌患者化疗期间的能量和蛋白质摄入，但对化疗期间的其他结局没有益处。关于放疗期间对患者或临床结局的影响，证据不足。需要进行随机试验研究在放疗期间对肺癌患者进行饮食咨询。
