a Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences , University of Madras , Chennai , India.
Nutr Cancer. 2014;66(1):38-46. doi: 10.1080/01635581.2014.847967. Epub 2013 Dec 9.
Prostate cancer becomes an ideal target for chemoprevention because of its high incidence and extended natural history. The consumption of quercetin (plant flavonoid) in diet is associated with decreased risk of disease and many cancers but then this was not elucidated in prostate malignancy. Hence, a study in which the male Sprague-Dawley rats were induced prostate cancer by hormone (testosterone) and carcinogen (MNU) and simultaneously supplemented with quercetin (200 mg/Kg body weight) thrice a week, was conducted. After the treatment period, rats were killed; ventral and dorsolateral lobes of the prostate were dissected. Histology and oxidative stress markers LPO, H2O2, and antioxidant GSH level were measured in both lobes. The lipid peroxidation, H2O2, in (MNU+T) treated rats were increased and GSH level was decreased, whereas simultaneous quercetin-treated rats reverted back to normal level in both ventral and dorsolateral regions. The different patterns of PIN were observed with associated hyperplasia and dysplasia; changes in these regions and the occurrence of this lesion were reduced in simultaneous quercetin-treated rats. The study concluded that dietary quercetin prevented MNU + T-induced prostate carcinogenesis on both ventral and dorsolateral lobes of Sprague-Dawley rats.
由于前列腺癌发病率高且自然病史较长，因此成为化学预防的理想目标。饮食中槲皮素（植物类黄酮）的摄入与疾病和多种癌症风险降低有关，但在前列腺恶性肿瘤中尚未阐明。因此，进行了一项研究，雄性 Sprague-Dawley 大鼠通过激素（睾丸酮）和致癌物（MNU）诱导前列腺癌，并同时每周三次补充槲皮素（200mg/Kg 体重）。治疗期结束后，处死大鼠；解剖前列腺的腹侧和背侧叶。测量两个叶的组织学和氧化应激标志物 LPO、H2O2 和抗氧化剂 GSH 水平。（MNU+T）处理大鼠的脂质过氧化、H2O2 增加，GSH 水平降低，而同时给予槲皮素治疗的大鼠在腹侧和背侧区域均恢复正常水平。观察到不同模式的 PIN 与相关的增生和发育不良有关；这些区域的变化和病变的发生在同时给予槲皮素治疗的大鼠中减少。研究结论是，饮食中的槲皮素可预防 MNU+T 诱导的 Sprague-Dawley 大鼠前列腺癌发生在腹侧和背侧叶。
