Fatima Nishat, Baqri Syed Shabihe Raza, Alsulimani Ahmad, Fagoonee Sharmila, Slama Petr, Kesari Kavindra Kumar, Roychoudhury Shubhadeep, Haque Shafiul
Department of Chemistry, Shia PG College, Lucknow 226003, India.
Department of Zoology, Shia PG College, Lucknow 226003, India.
Antioxidants (Basel). 2021 Oct 13;10(10):1606. doi: 10.3390/antiox10101606.
Oxygen is indispensable for most organisms on the earth because of its role in respiration. However, it is also associated with several unwanted effects which may sometimes prove fatal in the long run. Such effects are more evident in cells exposed to strong oxidants containing reactive oxygen species (ROS). The adverse outcomes of oxidative metabolism are referred to as oxidative stress, which is a staple theme in contemporary medical research. Oxidative stress leads to plasma membrane disruption through lipid peroxidation and has several other deleterious effects. A large body of literature suggests the involvement of ROS in cancer, ageing, and several other health hazards of the modern world. Plant-based cures for these conditions are desperately sought after as supposedly safer alternatives to mainstream medicines. Phytochemicals, which constitute a diverse group of plant-based substances with varying roles in oxidative reactions of the body, are implicated in the treatment of cancer, aging, and all other ROS-induced anomalies. This review presents a summary of important phytochemicals extracted from medicinal plants which are a part of Indian ethnomedicine and Ayurveda and describes their possible therapeutic significance.
由于氧气在呼吸过程中的作用，它对地球上的大多数生物来说是不可或缺的。然而，它也会带来一些不良影响，从长远来看，这些影响有时可能是致命的。在暴露于含有活性氧（ROS）的强氧化剂的细胞中，这种影响更为明显。氧化代谢的不良后果被称为氧化应激，这是当代医学研究的一个主要课题。氧化应激通过脂质过氧化导致质膜破坏，并产生其他几种有害影响。大量文献表明，活性氧与癌症、衰老以及现代世界的其他几种健康危害有关。人们迫切寻求基于植物的疗法来治疗这些疾病，因为它们被认为是比主流药物更安全的替代品。植物化学物质是一组多样的基于植物的物质，在人体的氧化反应中具有不同作用，它们与癌症、衰老以及所有其他由活性氧引起的异常情况的治疗有关。本综述总结了从药用植物中提取的重要植物化学物质，这些植物是印度民族医学和阿育吠陀医学的一部分，并描述了它们可能的治疗意义。
