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Host-adaptive antigenic variation in Bunyaviruses.

作者信息

James W S, Millican D

出版信息

J Gen Virol. 1986 Dec;67 ( Pt 12):2803-6. doi: 10.1099/0022-1317-67-12-2803.

DOI:10.1099/0022-1317-67-12-2803
PMID:2432166
Abstract

Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

摘要

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