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Relationship between glycoproteins of the viral envelope of bunyaviruses and antibody-dependent plaque enhancement.

作者信息

Millican D, Porterfield J S

出版信息

J Gen Virol. 1982 Nov;63 (Pt 1):233-6. doi: 10.1099/0022-1317-63-1-233.

DOI:10.1099/0022-1317-63-1-233
PMID:6890986
Abstract

Hamster antisera against three parental bunyaviruses, Batai, Bunyamwera and Maguari viruses, and six recombinant viruses which carried the nucleocapsid protein of one parent and the glycoproteins of the other, have been tested for their interaction with each of the nine viruses under study by two assays, plaque reduction neutralization and antibody-dependent plaque enhancement. Neutralization was clearly related to the specificity of the parental glycoproteins rather than the nucleoprotein, but the antibody-dependent plaque enhancement assay showed greater cross-reactivity.

摘要

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