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通过测量内毒素诱导的小鼠血浆中锌浓度变化以及急性期蛋白血清淀粉样P成分来检测小鼠体内的内毒素。

Detection of endotoxin in mice by measurement of endotoxin-induced changes in plasma concentrations of zinc and of the acute-phase protein serum amyloid P-component.

作者信息

Poole S, Gaines Das R E, Baltz M, Pepys M B

出版信息

J Pharm Pharmacol. 1986 Nov;38(11):807-10. doi: 10.1111/j.2042-7158.1986.tb04499.x.

DOI:10.1111/j.2042-7158.1986.tb04499.x
PMID:2432214
Abstract

Preparations of six bacterial endotoxins reduced plasma concentrations of zinc and increased concentrations of the acute-phase protein serum amyloid P component (SAP) in mice. The changes were sufficiently sensitive to permit use of either response in tests for endotoxin and hence for pyrogenic contamination.

摘要

六种细菌内毒素制剂可降低小鼠血浆中的锌浓度，并提高急性期蛋白血清淀粉样蛋白P成分（SAP）的浓度。这些变化足够敏感，可用于内毒素检测以及热原污染检测中的任何一种反应。

相似文献

1
Detection of endotoxin in mice by measurement of endotoxin-induced changes in plasma concentrations of zinc and of the acute-phase protein serum amyloid P-component.通过测量内毒素诱导的小鼠血浆中锌浓度变化以及急性期蛋白血清淀粉样P成分来检测小鼠体内的内毒素。
J Pharm Pharmacol. 1986 Nov;38(11):807-10. doi: 10.1111/j.2042-7158.1986.tb04499.x.
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Br J Exp Pathol. 1984 Aug;65(4):431-9.
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Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself.细菌重组人C反应蛋白的促炎作用是由细菌产物污染引起的，而非C反应蛋白本身所致。
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