Batista Thales Paulo, Santos Candice Amorim de Araújo Lima, Almeida Gustavo Fernandes Godoy
Instituto de Medicina Integral Professor Fernando Figueira, Faculdade Pernambucana de Saúde.
Arq Gastroenterol. 2013 Jul-Sep;50(3):236-42. doi: 10.1590/S0004-28032013000200042.
Gastric cancer is one of the most common cancers and a main cause of cancer-related death worldwide, since the majority of patients suffering of this malignancy are usually faced with a poor prognosis due to diagnosis at later stages. In order to improve treatment outcomes, the association of surgery with chemo and/or radiotherapy (multimodal therapy) has become the standard treatment for locally advanced stages. However, despite several treatment options currently available for management of these tumors, perioperative chemotherapy has been mainly accepted for the comprehensive therapeutic strategy including an appropriated D2-gastrectomy. This manuscript presents a (nonsystematic) critical review about the use of perioperative chemotherapy, with a special focus on the drugs delivery.
胃癌是最常见的癌症之一，也是全球癌症相关死亡的主要原因，因为大多数患有这种恶性肿瘤的患者通常由于在晚期才被诊断出来而面临预后不良的情况。为了改善治疗效果，手术与化疗和/或放疗相结合（多模式治疗）已成为局部晚期阶段的标准治疗方法。然而，尽管目前有几种治疗方案可用于这些肿瘤的管理，但围手术期化疗主要被接受用于包括适当的D2胃切除术在内的综合治疗策略。本文献对围手术期化疗的使用进行了（非系统性的）批判性综述，特别关注药物递送。
