真核生物起始因子3f表达降低是I-III期胃癌的不良预后因素。
Decreased expression of eukaryotic initiation factor 3f is an adverse prognostic factor for stage I-III gastric cancer.
作者信息
Li Guanghua, Wang Na, Sun Chuanjin, Li Bo
机构信息
Department of General Surgery, The Second Hospital of Shandong University, 247th Beiyuan Avenue, Jinan 250200, China.
出版信息
World J Surg Oncol. 2014 Mar 28;12:72. doi: 10.1186/1477-7819-12-72.
BACKGROUND
It has been demonstrated that eIF3f expression is significantly decreased in many human cancers, a fact which plays an important role in human cancer. However, the expression of eIF3f in gastric cancer (GC) is not well understood to date. Therefore, the aim of this study is to detect the expression of eIF3f in GC.
METHODS
The expression of eIF3f was examined by immunohistochemistry in tissues with stage I to III GC and adjacent non-cancerous tissues (ANCT) of 195 gastrectomy specimens; clinicopathological results, including survival, were analyzed.
RESULTS
The positive expression rate of eIF3f was significantly higher in ANCT tissues than in GC. eIF3f levels were correlated with more advanced tumor stages and likelihood of recurrence (all P<0.05). The Kaplan-Meier survival curves indicated that decreased expression of eIF3f could serve as a prognosis marker for poor outcome of GC patients (P=0.04).
CONCLUSIONS
eIF3f may play an important role in recurrence, thus representing a promising predictive marker for the prognosis of GC.
背景
已有研究表明，真核生物翻译起始因子3f（eIF3f）在多种人类癌症中的表达显著降低，这一事实在人类癌症中起着重要作用。然而，迄今为止，eIF3f在胃癌（GC）中的表达情况尚不清楚。因此，本研究旨在检测eIF3f在GC中的表达。
方法
采用免疫组织化学法检测195例胃癌切除标本中I至III期GC组织及癌旁非癌组织（ANCT）中eIF3f的表达；分析临床病理结果，包括生存率。
结果
eIF3f在ANCT组织中的阳性表达率显著高于GC组织。eIF3f水平与更晚期的肿瘤分期和复发可能性相关（均P<0.05）。Kaplan-Meier生存曲线表明，eIF3f表达降低可作为GC患者预后不良的预后标志物（P=0.04）。
结论
eIF3f可能在复发中起重要作用，因此是GC预后的一个有前景的预测标志物。
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