Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN, USA.
AIDS Rev. 2013 Oct-Dec;15(4):213-20.
Mitochondrial toxicity is implicated in some treatment-limiting antiretroviral therapy complications, and reports of mitochondrial dysfunction in untreated HIV infection suggest antiretroviral therapy independent effects of HIV. Several studies have explored associations between mtDNA haplogroups (patterns of mtDNA polymorphisms) and outcomes of HIV infection and/or antiretroviral therapy, but findings have been inconsistent. We systematically reviewed published studies examining mtDNA haplogroups in HIV-infected persons to summarize reported outcome associations, and to highlight potential future research directions. We identified 21 articles published from 2005-2013. Multiple different phenotypes were studied; most were antiretroviral therapy associated metabolic outcomes (e.g. lipodystrophy, insulin resistance, and dyslipidemia). Haplogroup H was associated with the most outcomes, including AIDS progression, CD4 T-cell recovery, cirrhosis (in hepatitis C coinfection), and metabolic outcomes. This review is the first to focus on the emerging area of mtDNA haplogroups in HIV, and summarizes the published literature on associations between mtDNA haplogroups and clinical outcomes in populations of European and African descent. Several reported associations require replication and ideally biological verification before definitive conclusions can be drawn, but research in this area has the potential to explain outcome disparities and impact clinical management of patients.
线粒体毒性与一些治疗限制的抗逆转录病毒治疗并发症有关，并且未经治疗的 HIV 感染中存在线粒体功能障碍的报告表明 HIV 具有抗逆转录病毒治疗的独立作用。一些研究已经探索了 mtDNA 单倍群（mtDNA 多态性模式）与 HIV 感染和/或抗逆转录病毒治疗结果之间的关联，但研究结果不一致。我们系统地回顾了已发表的研究 HIV 感染者中 mtDNA 单倍群的研究，以总结报告的结果关联，并强调潜在的未来研究方向。我们确定了 2005 年至 2013 年期间发表的 21 篇文章。研究了多种不同的表型；大多数是与抗逆转录病毒治疗相关的代谢结果（如脂肪营养不良、胰岛素抵抗和血脂异常）。单倍群 H 与最多的结果相关，包括艾滋病进展、CD4 T 细胞恢复、肝硬化（在丙型肝炎合并感染中）和代谢结果。这是第一篇专门针对 HIV 中 mtDNA 单倍群这一新兴领域的综述，总结了关于 mtDNA 单倍群与欧洲和非洲裔人群临床结果之间关联的已发表文献。一些报告的关联需要复制，最好进行生物学验证，然后才能得出明确的结论，但该领域的研究有可能解释结果差异并影响患者的临床管理。
