Holt Robert W, Leblond Frederic L, Pogue Brian W
J Opt Soc Am A Opt Image Sci Vis. 2013 Aug 1;30(8):1613-9. doi: 10.1364/JOSAA.30.001613.
The dependence of the sensitivity function in fluorescence tomography on the geometry of the excitation source and detection locations can severely influence an imaging system's ability to recover fluorescent distributions. Here a methodology for choosing imaging configuration based on the uniformity of the sensitivity function is presented. The uniformity of detection sensitivity is correlated with reconstruction accuracy in silico, and reconstructions in a murine head model show that a detector configuration optimized using Nelder-Mead minimization improves recovery over uniformly sampled tomography.
荧光断层成像中灵敏度函数对激发源几何形状和检测位置的依赖性会严重影响成像系统恢复荧光分布的能力。本文提出了一种基于灵敏度函数均匀性选择成像配置的方法。检测灵敏度的均匀性与计算机模拟中的重建精度相关，在小鼠头部模型中的重建结果表明，使用Nelder-Mead最小化优化的探测器配置比均匀采样断层成像能更好地恢复荧光分布。
