WHO Collaborating Centre for Nutrition and Oral Health, Centre for Oral Health Research, Institute for Ageing and Health, Newcastle University, UK.
J Dent Res. 2014 Jan;93(1):8-18. doi: 10.1177/0022034513508954. Epub 2013 Dec 9.
A systematic review of studies in humans was conducted to update evidence on the association between the amount of sugars intake and dental caries and on the effect of restricting sugars intake to < 10% and < 5% energy (E) on caries to inform the updating of World Health Organization guidelines on sugars consumption. Data sources included MEDLINE, EMBASE, Cochrane Database, Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences, China National Knowledge Infrastructure, Wanfang, and South African Department of Health. Eligible studies reported the absolute amount of sugars and dental caries, measured as prevalence, incidence, or severity. The review was conducted and reported in accordance with the PRISMA statement, and the evidence was assessed according to GRADE Working Group guidelines. From 5,990 papers identified, 55 studies were eligible - 3 intervention, 8 cohort, 20 population, and 24 cross-sectional. Data variability limited meta-analysis. Of the studies, 42 out of 50 of those in children and 5 out of 5 in adults reported at least one positive association between sugars and caries. There is evidence of moderate quality showing that caries is lower when free-sugars intake is < 10% E. With the < 5% E cut-off, a significant relationship was observed, but the evidence was judged to be of very low quality. The findings are relevant to minimizing caries risk throughout the life course.
对人类研究进行了系统回顾，以更新有关糖摄入量与龋齿之间关联的证据，以及限制糖摄入量<10%和<5%能量（E）对龋齿的影响的证据，为更新世界卫生组织关于糖消费的指南提供信息。数据来源包括 MEDLINE、EMBASE、Cochrane 数据库、Cochrane 中心对照试验注册库、拉丁美洲和加勒比健康科学、中国国家知识基础设施、万方和南非卫生部。合格的研究报告了糖的绝对量和龋齿，以患病率、发病率或严重程度衡量。该综述按照 PRISMA 声明进行和报告，证据根据 GRADE 工作组指南进行评估。从确定的 5990 篇论文中，有 55 项研究符合条件-3 项干预研究、8 项队列研究、20 项人群研究和 24 项横断面研究。数据变异性限制了荟萃分析。在这些研究中，50 项儿童研究中有 42 项，5 项成人研究中有 5 项报告了糖与龋齿之间至少存在一种正相关关系。有中等质量的证据表明，当游离糖摄入量<10%E 时，龋齿的发病率较低。当<5%E 时，观察到了显著的相关性，但证据质量被认为非常低。这些发现与在整个生命周期中最大限度地降低龋齿风险有关。
