Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Sq. E., New York, New York, 10003, USA.
Macromol Rapid Commun. 2014 Jan;35(1):27-43. doi: 10.1002/marc.201300792. Epub 2013 Dec 9.
Polymer-protein conjugates are biohybrid macromolecules derived from covalently connecting synthetic polymers with polypeptides. The resulting materials combine the properties of both worlds: chemists can engineer polymers to stabilize proteins, to add functionality, or to enhance activity; whereas biochemists can exploit the specificity and complexity that Nature has bestowed upon its macromolecules. This has led to a wealth of applications, particularly within the realm of biomedicine. Polymer-protein conjugation has expanded to include scaffolds for drug delivery, tissue engineering, and microbial inhibitors. This feature article reflects upon recent developments in the field and discusses the applications of these hybrids from a biomaterials standpoint.
聚合物-蛋白质缀合物是通过将合成聚合物与多肽共价连接而衍生的生物杂化大分子。由此产生的材料结合了两个世界的特性：化学家可以设计聚合物来稳定蛋白质，增加功能或增强活性；而生物化学家可以利用自然界赋予其大分子的特异性和复杂性。这导致了丰富的应用，特别是在生物医学领域。聚合物-蛋白质缀合物已扩展到包括药物输送、组织工程和微生物抑制剂的支架。本文反映了该领域的最新发展，并从生物材料的角度讨论了这些杂种的应用。
