Etminan Nima, Buchholz Bruce A, Dreier Rita, Bruckner Peter, Torner James C, Steiger Hans-Jakob, Hänggi Daniel, Macdonald R Loch
Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Dusseldorf, Germany,
Transl Stroke Res. 2014 Apr;5(2):167-73. doi: 10.1007/s12975-013-0294-x. Epub 2013 Oct 30.
The prevalence of unruptured intracranial aneurysms (UIAs) in the general population is up to 3%. Existing epidemiological data suggests that only a small fraction of UIAs progress towards rupture over the lifetime of an individual, but the surrogates for subsequent rupture and the natural history of UIAs are discussed very controversially at present. In case of rupture of an UIA, the case fatality is up to 50%, which therefore continues to stimulate interest in the pathogenesis of cerebral aneurysm formation and progression. Actual data on the chronological development of cerebral aneurysm has been especially difficult to obtain and, until recently, the existing knowledge in this respect is mainly derived from animal or mathematical models or short-term observational studies. Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms.
普通人群中未破裂颅内动脉瘤（UIA）的患病率高达3%。现有流行病学数据表明，在个体一生中，只有一小部分UIA会发展为破裂，但目前关于后续破裂的替代指标以及UIA的自然史存在很大争议。UIA破裂时，病死率高达50%，因此这继续激发了人们对脑动脉瘤形成和进展发病机制的兴趣。关于脑动脉瘤按时间顺序发展的实际数据尤其难以获得，直到最近，这方面的现有知识主要来自动物模型、数学模型或短期观察性研究。在此，我们综述了目前关于脑动脉瘤形成和进展的数据以及一种研究脑动脉瘤发育时间顺序的新方法。
