Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Transl Stroke Res. 2012 Sep;3(3):341-7. doi: 10.1007/s12975-012-0169-6. Epub 2012 May 5.
Inflammation is known to contribute to stroke evolution, and poststroke immune responses have been documented to emanate from the brain via microglia. However, circulating immune cells are increasingly recognized to play a significant role as well. Recent work has demonstrated the importance of the peripheral circulation and stroke pathogenesis. Understanding how the peripheral circulation contributes to ischemic brain injury may reveal important therapeutic targets and strategies. The use of bone marrow chimeras can be a useful tool in understanding the relative contributions of brain resident and peripheral inflammatory responses.
炎症被认为是中风演变的一个促成因素，并且已经有文献记录表明中风后的免疫反应是由小胶质细胞从大脑中发出的。然而，循环免疫细胞的作用也越来越受到重视。最近的研究表明，外周循环在中风发病机制中起着重要作用。了解外周循环如何导致缺血性脑损伤可能揭示重要的治疗靶点和策略。使用骨髓嵌合体可以成为理解大脑固有和外周炎症反应相对贡献的有用工具。
