常春藤水提取物作为胃溃疡预防剂。

Ivy water extracts as gastric ulcer preventive agents.

作者信息

Mulkijanyan K, Novikova Zh, Sulakvelidze M, Getia M, Mshvildadze V, Dekanosidze G

机构信息

Tbilisi State Medical University, I. Kutateladze Institute of Pharmacochemistry, Georgia; University of Quebec, Chicoutimi, Canada.

出版信息

Georgian Med News. 2013 Nov(224):63-6.

PMID:24323967

Abstract

In folk medicine the ivies (Hedera L. Fam.Araliaceae) are known as plants possessing diverse curative properties. A comparative phytochemical study of the biologically active water extracts of H. colchica and H. helix and evaluation of their ulcer preventive efficacy in ethanol-induced ulcer model in rats was carried out. Water extracts of H. colchica and H. helix (300 mg/kg, i.p.) significantly (p<0.01) decrease the ulcer index (0.50 and 1.38 vs 3.17 in control) and rise macroscopic curative ratio (84.2% and 56.6%, respectively). The results clearly indicate that pretreatment with water extract of H. colchica is preferable and further experiments are required to isolate the active principals responsible for itsantiulcerogenic activity.

摘要

在民间医学中，常春藤属植物（五加科常春藤属）被认为是具有多种治疗特性的植物。对科西嘉常春藤和洋常春藤具有生物活性的水提取物进行了比较植物化学研究，并评估了它们在大鼠乙醇诱导溃疡模型中的溃疡预防效果。科西嘉常春藤和洋常春藤的水提取物（300毫克/千克，腹腔注射）显著（p<0.01）降低溃疡指数（分别为0.50和1.38，而对照组为3.17），并提高宏观治愈率（分别为84.2%和56.6%）。结果清楚地表明，用科西嘉常春藤水提取物进行预处理更可取，需要进一步实验来分离其抗溃疡活性的活性成分。