Terry Fox Cancer Research Laboratory, China Medical University and Hospital, Taichung, Taiwan 40421, Republic of China,
Anticancer Res. 2013 Dec;33(12):5395-9.
The Non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs), and has been found to be involved in the carcinogenesis of many types of cancers including oral, prostate, breast and bladder cancer. However, the contribution of XRCC6 to childhood leukemia has yet to be studied. In the present study, we investigated the association of XRCC6 genotypes with the risk of childhood leukemia.
Two hundred and sixty-six patients with childhood leukemia and an equal number of age-matched healthy controls recruited in Central Taiwan, were genotyped investigating these polymorphisms' association with childhood leukemia.
As for XRCC6 promoter T-991C, patients carrying the TC genotype had a significantly increased risk of childhood leukemia compared with the TT wild-type genotype [odds ratio (OR)=2.30, 95% confidence interval (CI)=1.38-3.84, p=0.0047]. Meanwhile, the genotypes of XRCC6 promoter C-57G, A-31G and intron3 were not statistically associated with childhood leukemia risk.
Our findings suggest that the XRCC6 genotype could serve as a predictor of childhood leukemia risk and XRCC6 could serve as a target for personalized medicine and therapy.
非同源末端连接修复基因 XRCC6/Ku70 在修复 DNA 双链断裂（DSBs）中发挥重要作用，已发现其参与多种癌症的发生，包括口腔癌、前列腺癌、乳腺癌和膀胱癌。然而，XRCC6 对儿童白血病的贡献尚未得到研究。在本研究中，我们调查了 XRCC6 基因型与儿童白血病风险的关联。
在台湾中部招募了 266 名儿童白血病患者和与之年龄匹配的健康对照组，对这些多态性与儿童白血病的关联进行了基因型分析。
对于 XRCC6 启动子 T-991C，与 TT 野生型基因型相比，携带 TC 基因型的患者患儿童白血病的风险显著增加[比值比（OR）=2.30，95%置信区间（CI）=1.38-3.84，p=0.0047]。同时，XRCC6 启动子 C-57G、A-31G 和内含子 3 的基因型与儿童白血病风险无统计学关联。
我们的研究结果表明，XRCC6 基因型可作为儿童白血病风险的预测因子，XRCC6 可作为个体化医学和治疗的靶点。
