Lee Seung Mi, Park Jeong Woo, Kim Byoung Jae, Park Chan-Wook, Park Joong Shin, Jun Jong Kwan, Yoon Bo Hyun
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea ; Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
PLoS One. 2013 Dec 4;8(12):e79941. doi: 10.1371/journal.pone.0079941. eCollection 2013.
The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM.
METHODOLOGY/PRINCIPAL FINDINGS: The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were used for data analysis. The frequency of acute histologic chorioamnionitis was 24% in patients with preterm PROM who delivered preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Newborns born to mothers with histologic chorioamnionitis had significantly higher rates of adverse neonatal outcome (74% vs 51%; p<0.005) than those without histologic chorioamnionitis. This relationship remained significant after adjustment for gestational age at preterm PROM, gestational age at delivery, and exposure to antenatal corticosteroids.
CONCLUSIONS/SIGNIFICANCE: The presence of acute histologic chorioamnionitis is associated with adverse neonatal outcome in late preterm infants born to mothers with preterm PROM.
本研究的目的是确定急性组织学绒毛膜羊膜炎是否与早产胎膜早破后出生的晚期早产儿的不良新生儿结局相关。
方法/主要发现：在妊娠34周和36 6/7周之间分娩单胎早产新生儿的早产胎膜早破患者中，研究了急性组织学绒毛膜羊膜炎的存在与不良新生儿结局之间的关系。采用非参数统计进行数据分析。在妊娠34周和36 6/7周之间分娩早产新生儿的早产胎膜早破患者中，急性组织学绒毛膜羊膜炎的发生率为24%。患有组织学绒毛膜羊膜炎的母亲所生新生儿的不良新生儿结局发生率（74%对51%；p<0.005）显著高于未患有组织学绒毛膜羊膜炎的母亲所生新生儿。在对早产胎膜早破时的孕周、分娩时的孕周和产前使用糖皮质激素进行校正后，这种关系仍然显著。
结论/意义：急性组织学绒毛膜羊膜炎的存在与早产胎膜早破母亲所生晚期早产儿的不良新生儿结局相关。
