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从病因到结局:探究胎盘病理学与早产及神经发育临床风险之间的联系。

From etiology to outcome: investigating the link between placental pathology and clinical risk for preterm birth and neurodevelopment.

作者信息

Inder Terrie E

机构信息

Children's Hospital of Orange County, Orange, CA, USA.

Department of Pediatrics, University of California Irvine, Irvine, CA, USA.

出版信息

Pediatr Res. 2025 Jun 2. doi: 10.1038/s41390-025-04136-4.

DOI:10.1038/s41390-025-04136-4
PMID:40456917
Abstract

Understanding the etiology of preterm birth may provide insights into the risk for adverse neurodevelopmental outcome. This commentary contextualizes the study of El-Shahad et al alongside the complex multifactorial pathway to outcomes in the preterm infant, while noting some limitations within the study. Placental origins of preterm birth do not appear to provide major insights into risk for adverse neurodevelopmental outcome in the preterm infant.

摘要

了解早产的病因可能有助于深入了解不良神经发育结局的风险。本评论将埃尔-沙哈德等人的研究置于早产婴儿结局复杂的多因素途径背景下,同时指出该研究中的一些局限性。早产的胎盘起源似乎无法为早产婴儿不良神经发育结局的风险提供主要见解。

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1
From etiology to outcome: investigating the link between placental pathology and clinical risk for preterm birth and neurodevelopment.从病因到结局:探究胎盘病理学与早产及神经发育临床风险之间的联系。
Pediatr Res. 2025 Jun 2. doi: 10.1038/s41390-025-04136-4.
2
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本文引用的文献

1
Presumed etiology of preterm birth: brain injury and neurodevelopmental outcomes.早产的推测病因:脑损伤与神经发育结局。
Pediatr Res. 2025 Feb 25. doi: 10.1038/s41390-025-03945-x.
2
Defining the Neurologic Consequences of Preterm Birth.界定早产的神经学后果。
N Engl J Med. 2023 Aug 3;389(5):441-453. doi: 10.1056/NEJMra2303347.
3
Placental fetal vascular malperfusion, neonatal neurologic morbidity, and infant neurodevelopmental outcomes: a systematic review and meta-analysis.胎盘胎儿血管灌注不良、新生儿神经疾病发病率及婴儿神经发育结局:一项系统综述和荟萃分析。
Am J Obstet Gynecol. 2023 Dec;229(6):632-640.e2. doi: 10.1016/j.ajog.2023.06.014. Epub 2023 Jun 12.
4
Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.胎盘病理学对于理解常见的妊娠并发症和实现产科疾病的分类学改进是必要的。
Am J Obstet Gynecol. 2023 Feb;228(2):187-202. doi: 10.1016/j.ajog.2022.08.010. Epub 2022 Aug 13.
5
Preterm birth subtypes, placental pathology findings, and risk of neurodevelopmental disabilities during childhood.早产亚型、胎盘病理学表现与儿童期神经发育障碍风险。
Placenta. 2019 Aug;83:17-25. doi: 10.1016/j.placenta.2019.06.374. Epub 2019 Jun 14.
6
Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions.早产儿脑发育不良:重要性、细胞机制及潜在干预措施。
Pediatr Neurol. 2019 Jun;95:42-66. doi: 10.1016/j.pediatrneurol.2019.02.016. Epub 2019 Feb 27.
7
Associations of Newborn Brain Magnetic Resonance Imaging with Long-Term Neurodevelopmental Impairments in Very Preterm Children.新生儿脑磁共振成像与极早产儿长期神经发育障碍的关联
J Pediatr. 2017 Aug;187:58-65.e1. doi: 10.1016/j.jpeds.2017.04.059. Epub 2017 Jun 2.
8
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.急性绒毛膜羊膜炎和脐带炎:定义、病理特征及临床意义。
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S29-52. doi: 10.1016/j.ajog.2015.08.040.
9
Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates.绒毛膜羊膜炎与极低出生体重儿的早期儿童结局。
JAMA Pediatr. 2014 Feb;168(2):137-47. doi: 10.1001/jamapediatrics.2013.4248.
10
Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes.急性组织学绒毛膜羊膜炎是胎膜早破后晚期早产新生儿不良结局的一个危险因素。
PLoS One. 2013 Dec 4;8(12):e79941. doi: 10.1371/journal.pone.0079941. eCollection 2013.